| Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions. | |
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MedLine Citation:
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PMID: 21358864 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The treatment of digital ischemia remains difficult. Sildenafil (Viagra, Pfizer UK), a selective phosphodiesterase inhibitor, increases blood flow and is currently marketed for the treatment of erectile dysfunction. A case of a 57-year-old man with progressive episodic ischemia and pain of the fingertips resulting in finger tip ulceration is presented. After failure of medical and surgical management, a trial of oral sildenafil resulted in marked symptomatic improvement of his bilateral digital ischemia. Review of the literature shows that, particularly in patients with an underlying disease such as sclero-derma with a vasospastic component, a marked improvement in digital blood flow may be observed with sildenafil use. Overall, based on a number of case reports and preliminary animal studies in the literature, sildenafil appears to have a growing significance in the treatment of hand ischemia. Similarly, there is evidence that phosphodiesterase 5 inhibitors may be used as an adjunct to improving skin flap survival. |
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Authors:
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Wendy Ky Ng; Yishai Rosenblatt; Gerald B Brock; David B O'Gorman; Bing Siang Gan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique Volume: 18 ISSN: 1918-1507 ISO Abbreviation: Can J Plast Surg Publication Date: 2010 |
Date Detail:
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Created Date: 2011-03-01 Completed Date: 2011-07-14 Revised Date: 2011-07-26 |
Medline Journal Info:
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Nlm Unique ID: 9434932 Medline TA: Can J Plast Surg Country: Canada |
Other Details:
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Languages: eng Pagination: e5-9 Citation Subset: - |
Affiliation:
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The Hand and Upper Limb Centre; |
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