Document Detail


Phosphodiesterase inhibitors in vascular ischemia: A case report and review of their use in ischemic conditions.
MedLine Citation:
PMID:  21358864     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The treatment of digital ischemia remains difficult. Sildenafil (Viagra, Pfizer UK), a selective phosphodiesterase inhibitor, increases blood flow and is currently marketed for the treatment of erectile dysfunction. A case of a 57-year-old man with progressive episodic ischemia and pain of the fingertips resulting in finger tip ulceration is presented. After failure of medical and surgical management, a trial of oral sildenafil resulted in marked symptomatic improvement of his bilateral digital ischemia. Review of the literature shows that, particularly in patients with an underlying disease such as sclero-derma with a vasospastic component, a marked improvement in digital blood flow may be observed with sildenafil use. Overall, based on a number of case reports and preliminary animal studies in the literature, sildenafil appears to have a growing significance in the treatment of hand ischemia. Similarly, there is evidence that phosphodiesterase 5 inhibitors may be used as an adjunct to improving skin flap survival.
Authors:
Wendy Ky Ng; Yishai Rosenblatt; Gerald B Brock; David B O'Gorman; Bing Siang Gan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique     Volume:  18     ISSN:  1918-1507     ISO Abbreviation:  Can J Plast Surg     Publication Date:  2010  
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-07-14     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  9434932     Medline TA:  Can J Plast Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  e5-9     Citation Subset:  -    
Affiliation:
The Hand and Upper Limb Centre;
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