Document Detail

Phosphoarginine-adenosine triphosphate exchange detected in vivo in a microscopic nematode parasite by flow 31P FT-NMR spectroscopy.
MedLine Citation:
PMID:  1461129     Owner:  NLM     Status:  MEDLINE    
In vivo flow 31P NMR spectroscopy of a microscopic nematode, Steinernema carpocapsae, is described. Long-term viability was maintained during analysis by continuous circulation of an oxygenated suspension of the parasite through an NMR spectrometer. Saturation transfer and inversion recovery were employed under flowing conditions to investigate the kinetics of phosphoarginine<-->adenosine triphosphate exchange. The kinetic constants for the forward and reverse reactions were 0.37/s and 1.45/s, respectively. This report is the first to demonstrate a functional phosphagen kinase in the metabolism of a parasitic helminth.
S N Thompson; E G Platzer; R W Lee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  28     ISSN:  0740-3194     ISO Abbreviation:  Magn Reson Med     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-01-08     Completed Date:  1993-01-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Department of Entomology, University of California, Riverside 92521.
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MeSH Terms
Adenosine Triphosphate / metabolism*,  pharmacokinetics
Anoxia / metabolism
Arginine / analogs & derivatives*,  metabolism,  pharmacokinetics
Fourier Analysis
Larva / metabolism
Magnetic Resonance Spectroscopy / diagnostic use*
Nematoda / metabolism*
Organophosphorus Compounds / metabolism,  pharmacokinetics
Reg. No./Substance:
0/Organophosphorus Compounds; 1189-11-3/phospho-L-arginine; 56-65-5/Adenosine Triphosphate; 74-79-3/Arginine; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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