| Phospho-specific flow: fixating on the target. | |
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MedLine Citation:
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PMID: 22302900 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Targeted therapies are all the rage in oncology research these days. The problem remains as to how to confirm that the target is actually being hit in vivo. This report describes the application of phospho-specific flow cytometry to establish in vivo target inhibition in real time. |
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Authors:
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Mark Levis |
Publication Detail:
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Type: Comment; Journal Article Date: 2012-02-02 |
Journal Detail:
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Title: Clinical cancer research : an official journal of the American Association for Cancer Research Volume: 18 ISSN: 1078-0432 ISO Abbreviation: Clin. Cancer Res. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-16 Completed Date: 2012-06-28 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9502500 Medline TA: Clin Cancer Res Country: United States |
Other Details:
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Languages: eng Pagination: 1493-5 Citation Subset: IM |
Affiliation:
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Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. levisma@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use* Cytarabine / therapeutic use Etoposide / therapeutic use Female Humans Leukemia, Myeloid, Acute / metabolism* Male Mitoxantrone / therapeutic use Ribosomal Protein S6 / metabolism* Sirolimus / therapeutic use* TOR Serine-Threonine Kinases / antagonists & inhibitors* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA128864-03/CA/NCI NIH HHS; R01 CA128864-04/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Ribosomal Protein S6; 147-94-4/Cytarabine; 33419-42-0/Etoposide; 53123-88-9/Sirolimus; 65271-80-9/Mitoxantrone; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases |
| Comments/Corrections | |
Comment On:
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Clin Cancer Res. 2012 Mar 15;18(6):1716-25
[PMID:
22167413
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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