Document Detail


Phospho-specific flow: fixating on the target.
MedLine Citation:
PMID:  22302900     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Targeted therapies are all the rage in oncology research these days. The problem remains as to how to confirm that the target is actually being hit in vivo. This report describes the application of phospho-specific flow cytometry to establish in vivo target inhibition in real time.
Authors:
Mark Levis
Publication Detail:
Type:  Comment; Journal Article     Date:  2012-02-02
Journal Detail:
Title:  Clinical cancer research : an official journal of the American Association for Cancer Research     Volume:  18     ISSN:  1078-0432     ISO Abbreviation:  Clin. Cancer Res.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-06-28     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9502500     Medline TA:  Clin Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1493-5     Citation Subset:  IM    
Affiliation:
Department of Oncology, Johns Hopkins University, Baltimore, MD, USA. levisma@jhmi.edu
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
Cytarabine / therapeutic use
Etoposide / therapeutic use
Female
Humans
Leukemia, Myeloid, Acute / metabolism*
Male
Mitoxantrone / therapeutic use
Ribosomal Protein S6 / metabolism*
Sirolimus / therapeutic use*
TOR Serine-Threonine Kinases / antagonists & inhibitors*
Grant Support
ID/Acronym/Agency:
R01 CA128864-03/CA/NCI NIH HHS; R01 CA128864-04/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Ribosomal Protein S6; 147-94-4/Cytarabine; 33419-42-0/Etoposide; 53123-88-9/Sirolimus; 65271-80-9/Mitoxantrone; EC 2.7.1.1/MTOR protein, human; EC 2.7.1.1/TOR Serine-Threonine Kinases
Comments/Corrections
Comment On:
Clin Cancer Res. 2012 Mar 15;18(6):1716-25   [PMID:  22167413 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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