Document Detail

Phosphatidylkojibiosyl Diglyceride: metabolism and function as an anchor in bacterial cell membrane.
MedLine Citation:
PMID:  806764     Owner:  NLM     Status:  MEDLINE    
The recently discovered phosphoglycolipid, phosphatidylkojibiosyl diglyceride (PKD), was first observed as a biosynthetic by-product of glycosyl diglyceride metabolism in Streptococcus faecalis (faecium) ATCC 9790. Its structure is 1, 2-diacyl-3-O-alpha-Dglucopyranosyl-6'-O-phosphoryl- [1'', 2''-diacyl-3''-O-sn-glycerol]-alpha-D-glucopyranosyl)-sn-glycerol. The biosynthesis of phosphatidyl-kojibiosyl diglyceride occurs by a novel transphosphatidylation reaction in which a phosphatidyl glycerol to the primary alcohol function at the 6 position of the internal glucose of kojibiosyl diglyceride. The reaction is catalyzed by a membrane-derived enzyme. Phosphatidyl-kojibiosyl diglyceride is bound covalently through a phosphodiester bond to the polyglycerol phosphate moiety of membrane lipoteichoic acid from S. faecalis. Phosphatidylkojibiosyl diglyceride has four nonpolar long chain fatty acyl groups and appears to have the necessary physico-chemical properties to anchor the long hydrophilic glycerol phosphate polymer of lipoteichoic acid to the hydrophobic enviroment of the membrane of S. faecalis and probably other gram-positive bacteria as well.
R A Pieringer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lipids     Volume:  10     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1975-09-24     Completed Date:  1975-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-6     Citation Subset:  IM    
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MeSH Terms
Cell Membrane / physiology*
Diglycerides / physiology
Disaccharides / physiology
Enterococcus faecalis / physiology*
Models, Biological
Phospholipids / physiology*
Species Specificity
Reg. No./Substance:
0/Diglycerides; 0/Disaccharides; 0/Phospholipids

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