| Phosphatidylinositol turnover is not a general regulator of neuroblastoma cell differentiation: comparison between two differentiating agents, retinoic acid and gamma-interferon. | |
| | |
MedLine Citation:
|
PMID: 2492954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The turnover of phosphatidylinositol (PI) is believed to constitute a crucial step in the signaling pathways for stimulation of cells by a variety of bioactive substances, including differentiating agents; however decisive evidence for the idea has not been obtained. In the present paper, we investigated the involvement of PI turnover in cell differentiation using a human neuroblastoma cell line, LAN-1, which can be induced to differentiate along the neuronal pathway by both retinoic acid (RA) and gamma-interferon (gamma-IFN). Analysis of labelled phosphatidylinositol metabolites from prelabelled cells indicated a rapid decrease of inositol 1,4,5-trisphosphate and 1,2-diacylglycerol within 1 min of induction of LAN-1 cell differentiation by RA, while no changes were observed in gamma-IFN-treated cells. These findings indicate the occurrence of decreased inositol phospholipid turnover in RA-treated LAN-1 cells and suggest that phosphoinositide-derived metabolites may not constitute general regulators of cellular differentiation. |
| | |
Authors:
|
M Lanciotti; P Cornaglia-Ferraris; M Ponzoni |
Related Documents
:
|
2602914 - Rheumatoid synovial fluid reconstitutes the b-cell defect in cba/n mice. 7964484 - The t helper cell response in lyme arthritis: differential recognition of borrelia burg... 15778354 - Ex vivo characterization of the autoimmune t cell response in the hla-dr1 mouse model o... 11840454 - Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal... 16585264 - Endogenous irbp can be dispensable for generation of natural cd4+cd25+ regulatory t cel... 6985154 - Induction of 19s igm secretion in a murine pre-b cell line, 70z/3, by cell hybridizatio... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: FEBS letters Volume: 243 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1989 Jan |
Date Detail:
|
Created Date: 1989-04-03 Completed Date: 1989-04-03 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 285-8 Citation Subset: IM |
Affiliation:
|
Pediatric Oncology Research Laboratory, G. Gaslini Children's Hospital, Genoa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cell Differentiation
/
drug effects* Chromatography, High Pressure Liquid / methods Chromatography, Thin Layer Humans Interferon-gamma / pharmacology* Neuroblastoma Phosphatidylinositols / metabolism*, physiology Tretinoin / pharmacology* Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
|
0/Phosphatidylinositols; 302-79-4/Tretinoin; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epinephrine and the Ca2+ ionophore A23187 synergistically induce platelet aggregation without protei...
Next Document: Variability in electrophoretic mobility of Gi-like proteins: effect of SDS.