Document Detail


Phosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.
MedLine Citation:
PMID:  23765576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid-binding domains. The class I PI 3-kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3-kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform-specific signaling by PI 3-kinases.
Authors:
Rachel Schnur Salamon; Jonathan M Backer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  35     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  2014-04-21     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-11     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Class I Phosphatidylinositol 3-Kinases / genetics,  metabolism*
Gene Expression Regulation, Enzymologic*
Humans
Isoenzymes / metabolism
Models, Animal
Phosphatidylinositol Phosphates / metabolism*
Protein Interaction Domains and Motifs
Signal Transduction*
Grant Support
ID/Acronym/Agency:
1F31 AG040932-01/AG/NIA NIH HHS; 5T32 GM007491/GM/NIGMS NIH HHS; GM55692/GM/NIGMS NIH HHS; P01 CA 100324/CA/NCI NIH HHS; P01 CA100324/CA/NCI NIH HHS; R01 AG039632/AG/NIA NIH HHS; R01 GM055692/GM/NIGMS NIH HHS; T32 GM007491/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Phosphatidylinositol Phosphates; 0/phosphatidylinositol 3,4,5-triphosphate; EC 2.7.1.137/Class I Phosphatidylinositol 3-Kinases
Comments/Corrections

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