Document Detail

Phosphatidylinositol-3,4,5-trisphosphate: Tool of choice for class I PI 3-kinases.
MedLine Citation:
PMID:  23765576     Owner:  NLM     Status:  In-Data-Review    
Class I PI 3-kinases signal by producing the signaling lipid phosphatidylinositol(3,4,5) trisphosphate, which in turn acts by recruiting downstream effectors that contain specific lipid-binding domains. The class I PI 3-kinases comprise four distinct catalytic subunits linked to one of seven different regulatory subunits. All the class I PI 3-kinases produce the same signaling lipid, PIP3, and the different isoforms have overlapping expression patterns and are coupled to overlapping sets of upstream activators. Nonetheless, studies in cultured cells and in animals have demonstrated that the different isoforms are coupled to distinct ranges of downstream responses. This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform-specific signaling by PI 3-kinases. Editor's suggested further reading in BioEssays: Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling Abstract How does SHIP1/2 balance PtdIns(3,4)P2 and does it signal independently of its phosphatase activity? Abstract.
Rachel Schnur Salamon; Jonathan M Backer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  BioEssays : news and reviews in molecular, cellular and developmental biology     Volume:  35     ISSN:  1521-1878     ISO Abbreviation:  Bioessays     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8510851     Medline TA:  Bioessays     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-11     Citation Subset:  IM    
Copyright Information:
© 2013 WILEY Periodicals, Inc.
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
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