| Phosphatidylglucoside: Its structure, thermal behavior, and domain formation in plasma membranes. | |
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MedLine Citation:
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PMID: 22227109 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Phosphatidylglucoside (PtdGlc) is a unique glyco-glycerophospholipid that is found in both bacterial and mammalian cells. The discovery of PtdGlc in mammalian cells is relatively recent (Nagatsuka et al., 2001). Chemical structural analysis of the PtdGlc found in mammalian organs and cultured cells showed that PtdGlc is composed exclusively of a single pair of saturated fatty acid chains; the sn-1 chain is stearic acid (C18:0) and the sn-2 chain is arachidic acid (C20:0). PtdGlc forms distinct domains, which are different from cholesterol-based sphingolipid domains, on the outer leaflet of the plasma membrane. In this review, we summarize recent studies of PtdGlc. Special attention is paid to the thermal behavior of PtdGlc in a pure system and in mixtures with other lipid components that may relate to the formation of PtdGlc domains in biomembranes. Finally, we discuss proposed biological functions of PtdGlc based on recent experimental results. |
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Authors:
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Hiroshi Takahashi; Tomohiro Hayakawa; Motohide Murate; Peter Greimel; Yasuko Nagatsuka; Toshihide Kobayashi; Yoshio Hirabayashi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-27 |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: - ISSN: 1873-2941 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier Ireland Ltd. |
Affiliation:
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Biophysics Laboratory, Department of Chemistry and Chemical Biology, Gunma University, Maebashi, Gunma 371-8510, Japan; Lipid Biology Laboratory, RIKEN Advanced Science Institute, Wako, Saitama 351-0198, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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