Document Detail

Phosphatidylethanolamine methylation and hepatoma cell growth.
MedLine Citation:
PMID:  8694509     Owner:  NLM     Status:  MEDLINE    
Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). An isoform, PEMT2 has been cloned, expressed and localized to a mitochondria-associated membrane in rat liver. Expression of PEMT2 caused a decreased rate of cell division of cultured rat hepatoma cells. Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis. A role for PEMT2 in the regulation of hepatocyte cell division is also indicated by PEMT2 down-regulation in regenerating rat liver.
D E Vance; M Houweling; M Lee; Z Cui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Anticancer research     Volume:  16     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    1996 May-Jun
Date Detail:
Created Date:  1996-08-29     Completed Date:  1996-08-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  1413-6     Citation Subset:  IM    
Lipid and Lipoprotein Research Group, University of Alberta, Edmonton, Canada.
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MeSH Terms
Cell Division
Choline-Phosphate Cytidylyltransferase
Liver Neoplasms, Experimental / metabolism*,  pathology
Methyltransferases / physiology*
Nucleotidyltransferases / metabolism
Phosphatidylethanolamine N-Methyltransferase
Phosphatidylethanolamines / metabolism*
Reg. No./Substance:
0/Phosphatidylethanolamines; EC 2.1.1.-/Methyltransferases; EC N-Methyltransferase; EC 2.7.7.-/Nucleotidyltransferases; EC Cytidylyltransferase

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