| Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases. | |
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MedLine Citation:
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PMID: 19298865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane. |
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Authors:
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Shamshad Cockcroft |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-03-17 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1791 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2009-10-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 905-12 Citation Subset: IM |
Affiliation:
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Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. S.cockcroft@ucl.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ADP-Ribosylation Factors
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metabolism Amino Acid Sequence Amino Acids, Basic / metabolism Animals Enzyme Activation Humans Molecular Sequence Data Phosphatidic Acids / metabolism* Phospholipase D / metabolism Phosphotransferases (Alcohol Group Acceptor) / chemistry, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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//Cancer Research UK; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids, Basic; 0/Phosphatidic Acids; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 2.7.1.68/1-phosphatidylinositol-4-phosphate 5-kinase; EC 3.1.4.4/Phospholipase D; EC 3.6.5.2/ADP-Ribosylation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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