Document Detail

Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases.
MedLine Citation:
PMID:  19298865     Owner:  NLM     Status:  MEDLINE    
Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane.
Shamshad Cockcroft
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-17
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1791     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-25     Completed Date:  2009-10-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  905-12     Citation Subset:  IM    
Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK.
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MeSH Terms
ADP-Ribosylation Factors / metabolism
Amino Acid Sequence
Amino Acids, Basic / metabolism
Enzyme Activation
Molecular Sequence Data
Phosphatidic Acids / metabolism*
Phospholipase D / metabolism
Phosphotransferases (Alcohol Group Acceptor) / chemistry,  metabolism*
Grant Support
//Cancer Research UK; //Wellcome Trust
Reg. No./Substance:
0/Amino Acids, Basic; 0/Phosphatidic Acids; EC 2.7.1.-/Phosphotransferases (Alcohol Group Acceptor); EC 5-kinase; EC D; EC Factors

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