Document Detail

Phosphate compounds in bone scanning.
MedLine Citation:
PMID:  1141288     Owner:  NLM     Status:  MEDLINE    
Bone scanning with radioactive isotopes has been used to study a wide variety of disorders. Recently certain phosphate compounds, labelled with technetium, have been used as bone scanning agents. The comparative merits of three technetium-labelled phosphate compounds currently available for bone scanning--pyrophosphate, tripolyphosphate and ethylhydroxydiphosphonate (EHDP) have been compared in rabbits. Each substance was injected into ten rabbits and blood was withdrawn at regular intervals. The animals were killed at four hours and the blood and tissue samples were assayed for radioactivity. The results show that EHDP has a more rapid blood clearance than the other two agents, with a resultant improvement in the bone to soft-tissue ratio. Of the three substances investigated technetium-labelled EHDP was the best and might allow the technique of scanning to be used on a wide scale for the general study of bone and its pathology.
S P Hughes; K Jeyasingh; P J Lavender
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of bone and joint surgery. British volume     Volume:  57     ISSN:  0301-620X     ISO Abbreviation:  J Bone Joint Surg Br     Publication Date:  1975 May 
Date Detail:
Created Date:  1975-10-07     Completed Date:  1975-10-07     Revised Date:  2010-11-10    
Medline Journal Info:
Nlm Unique ID:  0375355     Medline TA:  J Bone Joint Surg Br     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  214-6     Citation Subset:  AIM; IM    
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MeSH Terms
Bone Diseases / diagnosis*
Bone and Bones / metabolism
Kidney / metabolism
Liver / metabolism
Muscles / metabolism
Phosphates / diagnostic use*,  metabolism
Radionuclide Imaging*
Skin / metabolism
Reg. No./Substance:
0/Phosphates; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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