| Phosphatase 2A puts the brakes on mTORC1 nutrient signaling. | |
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MedLine Citation:
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PMID: 20374954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nutrients such as amino acids (aa) and glucose mediate mammalian target of rapamycin complex 1 (mTORC1) signaling to control cell growth and metabolism. Recent studies (Yan et al., 2010) identify a contributor, PP2A phosphatase subunit PR61varepsilon, in regulating the aa-sensitive input to mTORC1. |
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Authors:
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Anand Selvaraj; George Thomas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell metabolism Volume: 11 ISSN: 1932-7420 ISO Abbreviation: Cell Metab. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-08 Completed Date: 2010-08-17 Revised Date: 2010-12-13 |
Medline Journal Info:
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Nlm Unique ID: 101233170 Medline TA: Cell Metab Country: United States |
Other Details:
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Languages: eng Pagination: 245-7 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cancer and Cell Biology, Metabolic Diseases Institute, University of Cincinnati, 2180 East Galbraith Road, Cincinnati, OH 45237, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glucose
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metabolism Humans Models, Biological Nutrition Processes / physiology* Obesity / complications, etiology* Phosphatidylinositol 3-Kinases / metabolism* Phosphorylation Protein Phosphatase 2 / metabolism* Protein-Serine-Threonine Kinases / metabolism Signal Transduction / physiology* Transcription Factors / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors; 0/mTORC1 complex, human; 50-99-7/Glucose; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/MAP4K3 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.1.3.16/Protein Phosphatase 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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