Document Detail


Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.
MedLine Citation:
PMID:  20374954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nutrients such as amino acids (aa) and glucose mediate mammalian target of rapamycin complex 1 (mTORC1) signaling to control cell growth and metabolism. Recent studies (Yan et al., 2010) identify a contributor, PP2A phosphatase subunit PR61varepsilon, in regulating the aa-sensitive input to mTORC1.
Authors:
Anand Selvaraj; George Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell metabolism     Volume:  11     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-08-17     Revised Date:  2013-09-30    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cancer and Cell Biology, Metabolic Diseases Institute, University of Cincinnati, 2180 East Galbraith Road, Cincinnati, OH 45237, USA.
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MeSH Terms
Descriptor/Qualifier:
Glucose / metabolism
Humans
Models, Biological
Nutrition Processes / physiology*
Obesity / complications,  etiology*
Phosphatidylinositol 3-Kinases / metabolism*
Phosphorylation
Protein Phosphatase 2 / metabolism*
Protein-Serine-Threonine Kinases / metabolism
Proteins
Signal Transduction / physiology*
Transcription Factors / metabolism*
Chemical
Reg. No./Substance:
0/Proteins; 0/Transcription Factors; 0/mechanistic target of rapamycin complex 1; 50-99-7/Glucose; EC 2.7.1.-/Phosphatidylinositol 3-Kinases; EC 2.7.11.1/MAP4K3 protein, human; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 3.1.3.16/Protein Phosphatase 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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