| Phosphanilic acid inhibits dihydropteroate synthase. | |
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MedLine Citation:
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PMID: 2514624 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intact cells of Pseudomonas aeruginosa were more susceptible to phosphanilic acid (PA) than cells of Escherichia coli. In cell extracts, the dihydropteroate synthases of P. aeruginosa and E. coli were about equally susceptible to inhibition by PA. These results suggest that cells of P. aeruginosa are more permeable to PA than cells of E. coli. Although a weak inhibitor, PA acted on dihydropteroate synthase in the same manner as the sulfonamides with which PA is structurally related. Inhibition of E. coli by PA in a basal salts-glucose medium was prevented by p-aminobenzoic acid (pABA). However, pABA did not protect P. aeruginosa from PA under these conditions, possibly because pABA itself exhibited an inhibitory effect. PA also appeared to have a second mode of action. The mechanism was not elucidated. |
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Authors:
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R G Eagon; A T McManus |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Antimicrobial agents and chemotherapy Volume: 33 ISSN: 0066-4804 ISO Abbreviation: Antimicrob. Agents Chemother. Publication Date: 1989 Nov |
Date Detail:
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Created Date: 1990-02-22 Completed Date: 1990-02-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1936-8 Citation Subset: IM |
Affiliation:
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Department of Microbiology, University of Georgia, Athens 30602. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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4-Aminobenzoic Acid
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pharmacology Aniline Compounds / pharmacology* Dihydropteroate Synthase / antagonists & inhibitors* Escherichia coli / drug effects, enzymology Indicators and Reagents Microbial Sensitivity Tests Pseudomonas aeruginosa / drug effects, enzymology Sulfanilamides / pharmacology Transferases / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Aniline Compounds; 0/Indicators and Reagents; 0/Sulfanilamides; 150-13-0/4-Aminobenzoic Acid; 5337-17-7/phosphanilic acid; 63-74-1/sulfanilamide; EC 2.-/Transferases; EC 2.5.1.15/Dihydropteroate Synthase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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