| Phosph-Akt1 expression is associated with a favourable prognosis in pancreatic cancer. | |
| | |
MedLine Citation:
|
PMID: 20697673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
INTRODUCTION: Akt, a serine/threonine protein kinase, mediates growth factor-associated cell survival. In several human cancers, including pancreatic cancer, constitutive activation of Akt (phosphorylated Akt, p-Akt) has been observed and may be associated with chemotherapy and radiotherapy resistance. However, there are contradictory viewpoints in p-Akt in pancreatic cancer on prognosis, and the clinical relevance of p-Akt in pancreatic cancer is not well understood. This study aims to investigate the expressions and relevance of Akt and p-Akt1 in pancreatic cancer tissues and their clinical significance. MATERIALS AND METHODS: The expressions of Akt and p-Akt in 74 surgically resected paraffin-embedded pancreatic ductal adenocarcinoma samples and 10 normal pancreatic tissue samples were examined by immunohistochemistry. The associations of their expression with clinicopathological and survival data were analysed. RESULTS: The positive expression rate of Akt and p-Akt1 were 87.8% and 83.8%, respectively, which were remarkably higher then those in normal pancreatic tissue (P <0.05). There was a positive correlation between the expression of Akt and p-Akt1. High p-Akt1 expression correlated with lower T stage (P = 0.004), while Akt was not associated with any clinicopathologic variables. Kaplan-Meier survival analysis revealed that higher expression of Akt, p-Akt1 were respectively correlated with favourable prognosis (16.0[4.7-27.3] vs 9.3[9.0-9.6] months, P = 0.007, and 23.0[12.2-33.8] vs 11.1[7.5-14.7] months, P = 0.004, respectively). Multivariate analysis identified p-Akt1 as a significant independent favourable prognostic factor (HR=0.421, P = 0.010). CONCLUSIONS: These results suggest that high p-Akt1 expression may be a favourable prognostic factor in pancreatic cancer. |
| | |
Authors:
|
Jun Liu; Sun Hong Cheng Sun; Sun Jing Sun; Chen Huang; Hong Hui Hu; Yu Biao Jin; Zheng Jun Qiu |
Related Documents
:
|
8113623 - Review of standards for reporting results of treatment of exocrine pancreatic cancer. 15802103 - Is sphincter of oddi manometry a risk factor for pancreatitis? a different view. 23302993 - Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murin... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Annals of the Academy of Medicine, Singapore Volume: 39 ISSN: 0304-4602 ISO Abbreviation: Ann. Acad. Med. Singap. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-08-10 Completed Date: 2010-12-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7503289 Medline TA: Ann Acad Med Singapore Country: Singapore |
Other Details:
|
Languages: eng Pagination: 548-7 Citation Subset: IM |
Affiliation:
|
Department of General Surgery, Shanghai Jiaotong University Affiliated First People's Hospital, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Carcinoma, Pancreatic Ductal / metabolism* Female Humans Immunohistochemistry Kaplan-Meier Estimate Male Middle Aged Pancreatic Neoplasms / metabolism* Prognosis Proto-Oncogene Proteins c-akt / metabolism* |
| Chemical | |
Reg. No./Substance:
|
EC 2.7.11.1/Proto-Oncogene Proteins c-akt |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: An eight year review of exercise-related cardiac arrests.
Next Document: Acceptability of medical students by patients from private and public family practices and specialis...