Document Detail

Phonophoresis of dexamethasone sodium phosphate may manage pain and symptoms of patients with carpal tunnel syndrome.
MedLine Citation:
PMID:  23042475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study was designed to compare the efficacy of iontophoresis and phonophoresis of dexamethasone sodium phosphate (Dex-P) treatment for mild to moderate carpal tunnel syndrome (CTS).
METHODS: Fifty-two hands in 34 consecutive patients with mild to moderate CTS confirmed by electromyography were allocated randomly into 2 groups. One group received iontophoresis of 0.4% Dex-P and the other group received phonophoresis of 0.4% Dex-P. Phonophoresis (using ultrasound 1 MHz, 5-cm probe, 1.0 W/cm, pulse 1:4, 5 min/session) and iontophoresis (using galvanic current, negative electrode, 2 mA/min, total dose 40 mA for 20 min) was applied over the wrist chin for 10 daily treatment sessions (5 sessions/wk). Measurements were performed before and after treatment and at follow-up 4 weeks later, and included pain assessment by visual analogue scale, electroneurographic measurement (motor and sensory latency, motor and sensory action potential amplitude), and pinch and grip strength.
RESULTS: Improvement was significantly more pronounced in the phonophoresis group than in the iontophoresis group for motor latency [mean difference 0.8 m/s; 95% confidence interval (CI), 0.5-1.1], motor action potential amplitude (4.1 mV; 95% CI, 3.0-5.2), finger pinch strength (31.6 N; 95% CI, 15.9-47.3), hand grip strength (27.1 N; 95% CI, 13.5-40.5), and pain relief (2.1 points on a 10-point scale; 95% CI, 1.3-2.9). Effects were sustained in the follow-up period.
DISCUSSION: Phonophoresis of Dex-P treatment was more effective than iontophoresis of Dex-P for treatment of CTS. Further study is needed to investigate the combination therapy effects of these treatments with other conservative treatments in CTS patients.
Amir H Bakhtiary; Elham Fatemi; Mitra Emami; Mojtaba Malek
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Clinical journal of pain     Volume:  29     ISSN:  1536-5409     ISO Abbreviation:  Clin J Pain     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-26     Revised Date:  2014-02-13    
Medline Journal Info:
Nlm Unique ID:  8507389     Medline TA:  Clin J Pain     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-53     Citation Subset:  IM    
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MeSH Terms
Action Potentials / drug effects,  physiology
Carpal Tunnel Syndrome / drug therapy*,  physiopathology
Dexamethasone / administration & dosage,  analogs & derivatives*,  therapeutic use
Glucocorticoids / administration & dosage,  therapeutic use*
Hand Strength / physiology
Middle Aged
Neural Conduction / drug effects,  physiology
Pain Measurement
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 312-93-6/dexamethasone 21-phosphate; 7S5I7G3JQL/Dexamethasone
Comment In:
Clin J Pain. 2013 Oct;29(10):924   [PMID:  23446078 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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