| Phonocardiographic recording of heterotopic cardiac graft function in the rat. I. Diagnosis of rejection. | |
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MedLine Citation:
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PMID: 366826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Daily simultaneous recordings of an electrocardiogram and an external thorax phonocardiogram and abdominal phonocardiogram were obtained in 24 rats with abdominal heart grafts so that rejection could be studied. The sounds recorded above the heterotopic heart are the result of a pressure differential between host and graft ventricle competing with one another. As soon as the contractility of the graft ventricle decreases below the contractility of the host ventricle, characteristic and specific changes occur in the abdominal phonocardiogram: the amplitude of the first sound becomes smaller while the timing of the second heart sound (aortic valve closure) is subsequently controlled by the host ventricle. These observations coincide with clinical and histological symptoms of rejection and are, therefore, of diagnostic value. In addition, a rough quantitative record of graft function is obtained by abdominal phonocardiography using the host's own cardiac function as a reference parameter. |
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Authors:
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J W Tauber; J M Blanchard; L P Tilley; R M Archibald; J B Zabriskie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Transplantation Volume: 26 ISSN: 0041-1337 ISO Abbreviation: Transplantation Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-03-24 Completed Date: 1979-03-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0132144 Medline TA: Transplantation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 409-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electrocardiography Graft Rejection Heart Transplantation* Male Myocardium / pathology Phonocardiography Rats Rats, Inbred BN Rats, Inbred Lew Transplantation, Homologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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