Document Detail

Phonocardiographic recording of heterotopic cardiac graft function in the rat. I. Diagnosis of rejection.
MedLine Citation:
PMID:  366826     Owner:  NLM     Status:  MEDLINE    
Daily simultaneous recordings of an electrocardiogram and an external thorax phonocardiogram and abdominal phonocardiogram were obtained in 24 rats with abdominal heart grafts so that rejection could be studied. The sounds recorded above the heterotopic heart are the result of a pressure differential between host and graft ventricle competing with one another. As soon as the contractility of the graft ventricle decreases below the contractility of the host ventricle, characteristic and specific changes occur in the abdominal phonocardiogram: the amplitude of the first sound becomes smaller while the timing of the second heart sound (aortic valve closure) is subsequently controlled by the host ventricle. These observations coincide with clinical and histological symptoms of rejection and are, therefore, of diagnostic value. In addition, a rough quantitative record of graft function is obtained by abdominal phonocardiography using the host's own cardiac function as a reference parameter.
J W Tauber; J M Blanchard; L P Tilley; R M Archibald; J B Zabriskie
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  26     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1978 Dec 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-4     Citation Subset:  IM    
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MeSH Terms
Graft Rejection
Heart Transplantation*
Myocardium / pathology
Rats, Inbred BN
Rats, Inbred Lew
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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