Document Detail


Phonation threshold pressure and flow in excised human larynges.
MedLine Citation:
PMID:  21792964     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES/HYPOTHESIS: To determine the phonation threshold pressure (PTP) and phonation threshold flow (PTF) in excised human larynges; determine the effects of posterior glottal width, glottal area, and gender on PTP and PTF; test the hypothesis that hysteresis is present in excised human laryngeal phonation; and compare these results to those from canine experiments and human subject measurements.
STUDY DESIGN: Induced phonation of excised human larynges in the laboratory.
METHODS: Nine human larynges were harvested within 24 hours postmortem. PTP and PTF at phonation onset and offset were measured on a bench apparatus. The effects of posterior glottal width, glottal area, and gender were examined.
RESULTS: Large intersubject variability was observed in PTP and PTF. PTP was comparable to those measured in vivo, whereas PTF was substantially higher. One-way ANOVA showed no significant dependence of PTP and PTF on posterior glottal width. Hysteresis was observed, with offset PTP and PTF lower than onset values. Offset measurements had significantly less variability than onset measurements (P = .012 for PTP, P = .0001 for PTF).
CONCLUSIONS: This study is one of the first to report onset and offset PTP and PTF in fresh excised human larynges. The high PTF observed likely reflects a large direct current flow component due to vocal fold bowing. Offset PTP and PTF values may be intrinsically more reliably measured than onset values. The large intersubject variability in PTP and PTF may have implication for the clinical application of these aerodynamic parameters of phonation.
Authors:
Ted Mau; Joseph Muhlestein; Sean Callahan; Kent T Weinheimer; Roger W Chan
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Laryngoscope     Volume:  121     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-27     Completed Date:  2011-09-23     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1743-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 The American Laryngological, Rhinological, and Otological Society, Inc.
Affiliation:
Departments of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. ted.mau@utsouthwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Aged, 80 and over
Female
Humans
Larynx / physiology*
Male
Middle Aged
Phonation / physiology*
Pressure
Grant Support
ID/Acronym/Agency:
R01 DC005788/DC/NIDCD NIH HHS; R01 DC005788/DC/NIDCD NIH HHS; R01 DC005788-08/DC/NIDCD NIH HHS; R01 DC006101/DC/NIDCD NIH HHS; R01 DC006101/DC/NIDCD NIH HHS; R01 DC006101-07/DC/NIDCD NIH HHS; R01 DC006101-07S1/DC/NIDCD NIH HHS; R01 DC006101S1/DC/NIDCD NIH HHS
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