| Pholedrine: a substitute for hydroxyamphetamine as a diagnostic eyedrop test in Horner's syndrome. | |
| | |
MedLine Citation:
|
PMID: 7876854 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Mydriatic responses to eyedrops containing the indirect acting sympathomimetic amines tyramine, hydroxyamphetamine, and pholedrine have been compared in 10 healthy subjects. Pholedrine, the n-methyl derivative of hydroxyamphetamine, at a concentration of 1% had effects similar to those produced by 0.5% hydroxyamphetamine itself. Pretreatment with topical guanethidine attenuated its responses and in 13 patients with unilateral Horner's syndrome it distinguished clearly those five patients who had preganglionic from the eight with postganglionic lesions. It is concluded that 1% pholedrine may be substituted for 0.5% hydroxyamphetamine, which is no longer available, as a diagnostic agent for use in Horner's syndrome. |
| | |
Authors:
|
A T Bates; S Chamberlain; M Champion; L Foley; E Hughes; B Jani; H Mehta; S E Smith |
Related Documents
:
|
20558944 - A japanese case of fragile-x-associated tremor/ataxia syndrome (fxtas). 16093114 - Horner's syndrome: a delayed complication after thoracostomy tube removal. 8651274 - A study of fraxe in mentally retarded individuals referred for fragile x syndrome (frax... 907534 - Gustatory phenomena after upper dorsal sympathectomy. 6409824 - Salivary iga in sjögren patients. 3819784 - Syndromes of a complex lesion of greater and lesser superficial petrosal nerves (parado... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 58 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 1995 Feb |
Date Detail:
|
Created Date: 1995-04-04 Completed Date: 1995-04-04 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 215-7 Citation Subset: IM |
Affiliation:
|
Department of Clinical Pharmacology, United Medical School, Guy's Hospital, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Female Guanethidine / diagnostic use Horner Syndrome / diagnosis* Humans Male Methamphetamine / analogs & derivatives*, diagnostic use Middle Aged Ophthalmic Solutions* Pupil / drug effects Sympathomimetics / diagnostic use* Tyramine / diagnostic use p-Hydroxyamphetamine / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Ophthalmic Solutions; 0/Sympathomimetics; 103-86-6/p-Hydroxyamphetamine; 370-14-9/pholedrine; 51-67-2/Tyramine; 537-46-2/Methamphetamine; 55-65-2/Guanethidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rhabdomyolysis and acute encephalopathy in late onset medium chain acyl-CoA dehydrogenase deficiency...
Next Document: Loss of heterozygosity for DNA polymorphisms mapping to chromosomes 10 and 17 and prognosis in patie...