Document Detail


Phlogistic properties of peptidoglycan-polysaccharide polymers from cell walls of pathogenic and normal-flora bacteria which colonize humans.
MedLine Citation:
PMID:  8406849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PG-PS polymers which can induce experimental chronic inflammation in joints and other tissues can be isolated from the cell walls of human pathogens, such as group A streptococci, as well as from certain indigenous bacterial species which colonize the human intestinal tract. The structural and biological properties that are required for cell wall fragments to express this remarkable activity are still not well defined, but polymer size, resistance to tissue enzymes, and capacity to sustain activation of complement, macrophages, neutrophils, and T cells are properties associated with the most active preparations. There is increasing evidence that PG-PS structures with arthropathogenic activity occur in the human intestinal lumen and that these polymers can be translocated systemically. These observations support the concept that PG-PS, derived from a variety of bacterial species, can be part of the etiology of rheumatoid arthritis and other chronic inflammatory diseases. Since the PG component provides a common element to which all individuals are exposed, it follows that susceptibility is related to efficiency of disposal of bacterial cell wall debris, as well as to cytokine networks and immune cell function (51).
Authors:
J H Schwab
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Infection and immunity     Volume:  61     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1993-11-24     Completed Date:  1993-11-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4535-9     Citation Subset:  IM    
Affiliation:
Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599.
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MeSH Terms
Descriptor/Qualifier:
Arthritis, Infectious / etiology
Cell Wall / chemistry
Enteritis / etiology*
Humans
Peptidoglycan / toxicity*
Polymers / toxicity
Polysaccharides, Bacterial / toxicity*
Grant Support
ID/Acronym/Agency:
AR39480/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Peptidoglycan; 0/Polymers; 0/Polysaccharides, Bacterial
Comments/Corrections

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