| Phlebotomy increases cadmium uptake in hemochromatosis. | |
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MedLine Citation:
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PMID: 10753085 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intestinal absorption of the nephrotoxic environmental pollutant cadmium increases markedly when iron stores are depleted. This may be mediated by an up regulation of the recently identified mucosal transporter DMT1 (Nramp2 or DCT1) for divalent cations. We tested whether the highly increased iron absorption in hereditary hemochromatosis (HH) was accompanied by an enhanced absorption of cadmium and lead. Cadmium and lead in blood and iron status markers were determined in 21 nonsmoking subjects with HH genetically tested for the HFE mutations and in 21 nonsmoking controls matched for age and sex. In subjects with HH on maintenance phlebotomy treatment, blood concentrations of cadmium, but not lead, were significantly higher than in paired controls. There was a strong age-independent positive association between blood cadmium and the number of years of phlebotomy treatment. Blood lead showed a similar but less pronounced consequence of treatment. All HH subjects with lower blood cadmium than the corresponding controls had either no mutation in the HFE gene, were not phlebotomized, or were phlebotomized for only a limited time. Our findings indicate that the treatment rather than the disease increased the cadmium uptake in homozygous HH. Further studies are needed to confirm whether the disease decreased cadmium absorption and whether the absorption was dependent on the genotype. |
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Authors:
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A Akesson; P Stål; M Vahter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Environmental health perspectives Volume: 108 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-06-29 Completed Date: 2000-06-29 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 289-91 Citation Subset: IM |
Affiliation:
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Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden. Agneta.Akesson@imm.ki.se |
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Age Factors Aged Aged, 80 and over Cadmium / pharmacokinetics* Female Genotype Hemochromatosis / genetics, metabolism* Humans Lead / pharmacokinetics* Male Middle Aged Phlebotomy / adverse effects* |
| Chemical | |
Reg. No./Substance:
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7439-92-1/Lead; 7440-43-9/Cadmium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 4 Year: 2000 Volume: 108 Issue: 4 First Page: 289 Last Page: 291 ID: 1638026 PubMed Id: 10753085 Publisher Item Identifier: sc271_5_1835 |
| Phlebotomy increases cadmium uptake in hemochromatosis. | |
| A Akesson | |
| P St?l | |
| M Vahter | |
| Institute of Environmental Medicine, Division of Metals and Health, Karolinska Institutet, Stockholm, Sweden. Agneta.Akesson@imm.ki.se |
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