| Philothermal response of polymorphonuclear leukocytes in dementia of the Alzheimer type. | |
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MedLine Citation:
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PMID: 7133279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The philothermal response, i.e., the tendency of polymorphonuclear leukocytes (PMNs) to migrate along a temperature gradient toward warmer temperatures, was evaluated in 11 patients with a clinical diagnosis of dementia of the Alzheimer type (DAT) and compared to 11 age and sex-matched mentally normal individuals. While the total number of migrating PMNs did not differ significantly between these two groups, there was a significant difference in the spatial distribution of the responding cell population. The numerical parameter, R, has been introduced to provide a quantitative measure of the distribution of populations characterized by differences in motile behavior. This R value was unusually high for 10 of the DAT patients but only one of the comparison individuals. No relation between R and duration of illness, age, or sex was detected. These preliminary findings, based on a small number of clinically diagnosed DAT patients, suggest that the philothermal response may represent a biological marker with diagnostic usefulness for at least one subgroup of DAT patients. |
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Authors:
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L F Jarvik; S S Matsuyama; J O Kessler; T K Fu; S Y Tsai; E O Clark |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neurobiology of aging Volume: 3 ISSN: 0197-4580 ISO Abbreviation: Neurobiol. Aging Publication Date: 1982 |
Date Detail:
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Created Date: 1982-12-21 Completed Date: 1982-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8100437 Medline TA: Neurobiol Aging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alzheimer Disease / physiopathology* Cell Movement Dementia / physiopathology* Female Humans Male Middle Aged Neutrophils / physiology* Reference Values Temperature |
| Grant Support | |
ID/Acronym/Agency:
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MH31357/MH/NIMH NIH HHS; MH36205/MH/NIMH NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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