Document Detail

Philosophy of antiarrhythmic approaches to ventricular tachyarrhythmias close to the 21st century.
MedLine Citation:
PMID:  9973859     Owner:  NLM     Status:  MEDLINE    
The scientific basis and the reasoning underlying the changes in antiarrhythmic approaches to ventricular arrhythmias during recent decades are discussed. The early enthusiasm in the use of antiarrhythmic drugs in patients after myocardial infarction to prevent sudden cardiac death was severely affected by the results of the Cardiac Arrhythmia Suppression Trial (CAST) which show an increased mortality of patients on sodium-channel antagonist antiarrhythmic drugs. A transient euphoria for drugs that prolong repolarization received criticism after premature termination of the Survival With Oral D-sotalol-trial (SWORD). Recently, attention has focused on the use of the implantable cardioverter defibrillator in both secondary and primary prevention of sudden death. In contrast, catheter ablation, although very useful in supraventricular tachycardia, still plays a limited role in the management of ventricular tachyarrhythmias in the presence of organic heart disease.
G Breithardt; W Haverkamp; D Böcker; M Borggrefe
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology     Volume:  17     ISSN:  0870-2551     ISO Abbreviation:  Rev Port Cardiol     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1999-03-05     Completed Date:  1999-03-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8710716     Medline TA:  Rev Port Cardiol     Country:  PORTUGAL    
Other Details:
Languages:  eng     Pagination:  981-91     Citation Subset:  IM    
Department of Cardiology and Angiology, Institute of Arteriosclerosis Research, Westfalian Wilhems-University of Münster, Germany.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Clinical Trials as Topic
Death, Sudden, Cardiac / prevention & control
Defibrillators, Implantable
Philosophy, Medical*
Tachycardia, Ventricular / drug therapy*
Time Factors
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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