Document Detail


Philadelphia negative, Bcr-Abl positive chronic myeloid leukemia associated with pure red cell aplasia.
MedLine Citation:
PMID:  12866588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pure red cell aplasia (PRCA) is a rare disorder which is associated with thymoma, viral infections and autoimmune diseases. A few cases of PRCA during the clinical course of CML have been reported and these usually terminate in blastic crisis and death, suggesting a poor prognosis. However, only one case of Philedelphia chromosome negative, Bcr-Abl positive CML associated with PRCA has been reported. Here, we present a second case report of a Philedelphia negative, Bcr-Abl positive CML associated with PRCA who was unresponsive to all the chemotherapeutic regimens. We conclude that the present case supports the idea that the development of PRCA in the course of CML may be a bad prognostic sign.
Authors:
S Karti; M Yilmaz; M Sonmez; R Akdogan; S Ersoz; F Ucar; E Ovali
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  22     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-17     Completed Date:  2004-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  341-2     Citation Subset:  IM    
Affiliation:
Dept. of Internal Medicine, Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey. samikarti@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Fusion Proteins, bcr-abl / genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis,  pathology
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis*,  pathology*
Male
Middle Aged
Prognosis
Red-Cell Aplasia, Pure / diagnosis*,  pathology*
Chemical
Reg. No./Substance:
0/Fusion Proteins, bcr-abl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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