Document Detail

Philadelphia negative, Bcr-Abl positive chronic myeloid leukemia associated with pure red cell aplasia.
MedLine Citation:
PMID:  12866588     Owner:  NLM     Status:  MEDLINE    
Pure red cell aplasia (PRCA) is a rare disorder which is associated with thymoma, viral infections and autoimmune diseases. A few cases of PRCA during the clinical course of CML have been reported and these usually terminate in blastic crisis and death, suggesting a poor prognosis. However, only one case of Philedelphia chromosome negative, Bcr-Abl positive CML associated with PRCA has been reported. Here, we present a second case report of a Philedelphia negative, Bcr-Abl positive CML associated with PRCA who was unresponsive to all the chemotherapeutic regimens. We conclude that the present case supports the idea that the development of PRCA in the course of CML may be a bad prognostic sign.
S Karti; M Yilmaz; M Sonmez; R Akdogan; S Ersoz; F Ucar; E Ovali
Related Documents :
17481728 - On the evidence for seasonal variation in the onset of acute lymphoblastic leukemia (all).
8207978 - In vivo clonal evolution of pre-b to b-cell acute lymphoblastic leukemia in childhood.
12946218 - Chronic myelomonocytic leukemia with abnormal bone marrow eosinophils.
12539578 - Application of cd45/ssc gating multiparameter flow cytometry in the classification of a...
24605168 - Silver and gold-catalyzed multicomponent reactions.
15841368 - Infantile myofibromatosis: a most unusual cause of gastric outlet obstruction.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of experimental & clinical cancer research : CR     Volume:  22     ISSN:  0392-9078     ISO Abbreviation:  J. Exp. Clin. Cancer Res.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-07-17     Completed Date:  2004-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8308647     Medline TA:  J Exp Clin Cancer Res     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  341-2     Citation Subset:  IM    
Dept. of Internal Medicine, Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fusion Proteins, bcr-abl / genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis,  pathology
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / diagnosis*,  pathology*
Middle Aged
Red-Cell Aplasia, Pure / diagnosis*,  pathology*
Reg. No./Substance:
0/Fusion Proteins, bcr-abl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Demyelinating disease in monoclonal gammopathy of undetermined significance.
Next Document:  Prospective cohort study comparing subcutaneous and sub-superficial musculoaponeurotic system flaps ...