Document Detail

Philadelphia chromosome-positive acute lymphoblastic leukemia secondary to chemoradiotherapy for Ewing sarcoma. Report of two cases and concise review of the literature.
MedLine Citation:
PMID:  15609284     Owner:  NLM     Status:  MEDLINE    
Survivors of childhood solid tumors including Ewing sarcoma (ES) have an increased risk of secondary malignant neoplasms (SMNs) as a consequence of exposure to chemotherapy and/or radiation (see: Bhatia S, Sklar C. Nat Rev Cancer 2002;2:124-132). The most common hematologic SMNs are myelodysplasia (MDS) and acute myelogenous leukemia (AML). Acute lymphoblastic leukemia (ALL) is uncommon in this patient population, and Philadelphia chromosome positive (Ph+) ALL in particular, is rare. We report herein two cases of young adult patients who were both diagnosed with Ph+ ALL 19 years after successful treatment for ES with combined modality therapy. A review of the relevant literature follows the case reports.
David S Snyder; Anthony S Stein; Margaret R O'Donnell; Karl Gaal; Marilyn L Slovak; Stephen J Forman
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  78     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-23     Completed Date:  2005-02-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-8     Citation Subset:  IM    
Division of Hematology, City of Hope National Medical Center, Duarte, CA 91010, USA.
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MeSH Terms
Antineoplastic Agents / adverse effects*
Bone Neoplasms / drug therapy*,  radiotherapy*
Combined Modality Therapy / adverse effects
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
Radiation Injuries / complications*
Sarcoma, Ewing's / drug therapy*,  radiotherapy*
Time Factors
Grant Support
Reg. No./Substance:
0/Antineoplastic Agents

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