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Pheripheral Airway Responsiveness to Sub-maximal Exercise in Asymptomatic Cigarette Smokers.
MedLine Citation:
PMID:  22609499     Owner:  NLM     Status:  In-Data-Review    
Background Cigarette smoking is one of the cardinal causes for the development of bronchial hyperresponsiveness among the smokers. Objectives This study was perspectively designed to determine the peripheral bronchial responsiveness to sub-maximal exercise challenge in the asymptomatic smokers. Methods The subjects were between age of 18-25 years without any findings of cardiorespiratory diseases. We performed the 5 min step test exercise at intensity of 80 to 90% of maximum predicted heart rate in 42 young adult male asymptomatic smokers to examine the effect of cigarette smoking on airway responsiveness. Forced expiratory spirogram was recorded before and at 0, 5, 10, 15 min after the completion of exercise. Pre- to post exercise drop in Forced Expiratory Volume in first second = 15% was considered hyperresponsive to the challenge. Result The analysis of data (mean +/- SE) indicated the bronchial hyper-responsiveness in 22 (52%) smokers. The post exercise recovery time pattern showed drop in forced expiratory spirogram from the resting baseline in the responsive smokers and the maximum percentage fall in the parameters or increase in airway resistance which reflect the peripheral airway integrity such as Forced Expiratory Flow 25% (20.30 +/- 2.18 Vs 7.88 +/-3.23, p less than 0.01), Forced Expiratory Flow 50% (18.46 +/- 4.40 Vs 1.93 +/-2.78, p less than 0.01), Forced Expiratory Flow 75% (23.94+/-3.68 Vs 0.80 +/-4.72, p less than 0.001) and Forced Expiratory Flow 25-75% (32.50+/-4.79 Vs 3.64+/-3.32, p less than 0.001) was significantly higher in the responsive than non-responsive subgroup of the smokers. Conclusion The occurrence of peripheral airway resistance is more in the responsive than nonresponsive subset of smokers to the exercise challenge and hence more prone to develop obstructive airway disease in the long run.
B R Pokhrel; S Chatopadhyaya; B H Paudel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kathmandu University medical journal (KUMJ)     Volume:  9     ISSN:  1812-2078     ISO Abbreviation:  Kathmandu Univ Med J (KUMJ)     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2012-05-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101215359     Medline TA:  Kathmandu Univ Med J (KUMJ)     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Department of Physiology, Kathmandu University of School Medical Sciences, Dhulikhel, Nepal.
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