| Pheochromocytoma and medullary thyroid carcinoma in a pregnant multiple endocrine neoplasia-2A patient. | |
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MedLine Citation:
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PMID: 20672905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We describe a rare combination of pheochromocytoma and medullary thyroid carcinoma (MTC) during pregnancy. METHODS: Twenty-three-years old lady, primigravida, was detected to be hypertensive at 12 weeks of gestation and was found to have left adrenal mass on routine obstetric scan. She had a goitre on examination which was proven to be MTC on fine needle aspiration cytology. Twenty-four hours urinary vanillyl mandelic acid and serum calcitonin levels were elevated. After adequate α and β blockade she underwent left adrenalectomy during second trimester of gestation with no significant perioperative complications. Twelve days later she underwent total thyroidectomy. RESULTS: Adrenal mass was confirmed to be pheochromocytoma while MTC was confirmed in the thyroidectomy specimen. Post-operatively, she was normotensive and delivered a healthy female baby at term. Both mother and the baby tested positive for germline RET mutation (C634W) in exon 11. CONCLUSION: We describe a rare case of pregnant multiple endocrine neoplasia-2A patient with pheochromocytoma and MTC. |
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Authors:
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Vijaya Sarathi; Tushar R Bandgar; Padma S Menon; Nalini S Shah |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-07-30 |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 27 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-05 Completed Date: 2011-12-05 Revised Date: 2012-06-04 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 533-5 Citation Subset: IM |
Affiliation:
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Department of Endocrinology, Seth G S Medical College and KEM Hospital, Mumbai, Maharashtra, India. drvijayasarathi@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Gland Neoplasms
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diagnosis*,
genetics,
physiopathology,
surgery Adult Amino Acid Substitution Carcinoma, Medullary / diagnosis*, genetics, physiopathology, surgery Female Humans Hypertension, Pregnancy-Induced / etiology Live Birth Multiple Endocrine Neoplasia Type 2a / diagnosis*, genetics, physiopathology, surgery Mutation Pheochromocytoma / diagnosis*, genetics, physiopathology, surgery Pregnancy Pregnancy Complications, Neoplastic / diagnosis*, genetics, physiopathology, surgery Pregnancy Trimester, First Proto-Oncogene Proteins c-ret / genetics Thyroid Neoplasms / diagnosis*, genetics, physiopathology, surgery Young Adult |
| Chemical | |
Reg. No./Substance:
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EC 2.7.10.1/Proto-Oncogene Proteins c-ret; EC 2.7.10.1/RET protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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