| Pheochromocytoma in a patient with end-stage renal disease. | |
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MedLine Citation:
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PMID: 11560309 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pheochromocytoma is a rare tumor. To our knowledge only 15 cases have been reported in patients with end-stage renal disease (ESRD). We describe a 46-year-old woman with ESRD and a history of paroxysmal and difficult-to-control hypertension. During anesthesia for a surgical procedure, the patient experienced blood pressure lability with systolic blood pressures ranging from 76 to 360 mm Hg. Serum catecholamine concentrations were 2,698 pg/ mL (reference value, <750 pg/mL) for norepinephrine, 33 pg/mL (<110 pg/mL) for epinephrine, and 55 pg/mL (<30 pg/mL) for dopamine. The concentrations of plasma metanephrines were 6.84 nmol/L (<0.50 nmol/L) for metanephrine and 14.64 nmol/L (<0.90 nmol/L) for normetanephrine. Abdominal computed tomography showed a right-sided, 4-cm mass posterior to the infrahepatic inferior vena cava. Following blood pressure control with alpha- and beta-adrenergic blockade, the mass was removed. Pathologic examination demonstrated the mass was a pheochromocytoma. The maximum postoperative systolic blood pressure was 160 mm Hg. Postoperative plasma normetanephrine concentration was 2.80 nmol/L, and metanephrine was obscured by interfering substances. This case report and literature review emphasizes the difficulty in diagnosing pheochromocytomas in patients with ESRD despite the myriad of available diagnostic tests. |
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Authors:
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J A Godfrey; O B Rickman; A W Williams; G B Thompson; W F Young |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Mayo Clinic proceedings. Mayo Clinic Volume: 76 ISSN: 0025-6196 ISO Abbreviation: Mayo Clin. Proc. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-09-18 Completed Date: 2001-12-04 Revised Date: 2007-10-29 |
Medline Journal Info:
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Nlm Unique ID: 0405543 Medline TA: Mayo Clin Proc Country: United States |
Other Details:
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Languages: eng Pagination: 953-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Mayo Clinic, Rochester, Minn 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Chemical Analysis Female Follow-Up Studies Humans Kidney Failure, Chronic / complications*, diagnosis, therapy Middle Aged Pheochromocytoma / complications*, diagnosis*, surgery Renal Dialysis Tomography, X-Ray Computed Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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