| Phenytoin transfer across the in situ perfused rat term placenta. | |
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MedLine Citation:
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PMID: 9399343 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transfer of phenytoin (PHT) across the rat term placenta perfused in situ was investigated and compared with that of antipyrine (AP) as a marker of passive diffusion. PHT was shown to cross the placenta with similar kinetics as AP did. Both the first order transfer constant (ktr = 0.070 min-1) and the first order equilibration constant (keq = 0.027 min-1) of PHT were comparable to those of AP (ktr = 0.046 min-1, keq = 0.022 min-1). Similarly, there were significant differences between PHT and AP in the foeto-maternal concentration ratio at equilibrium (FMCReq = 1.01 and 1.09, respectively). The present data indicate that the transfer of PHT through the rat placenta is governed by the same principles as that of AP, i.e. by the mechanism of passive diffusion. Surprisingly, maternal plasma protein binding of PHT (60.5%) did not seem to influence either its rate of transfer or its eventual foeto-maternal concentration ratio. |
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Authors:
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F Staud; Z Fendrich; O Jindrová; M Láznícek |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Die Pharmazie Volume: 52 ISSN: 0031-7144 ISO Abbreviation: Pharmazie Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-01-29 Completed Date: 1998-01-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9800766 Medline TA: Pharmazie Country: GERMANY |
Other Details:
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Languages: eng Pagination: 871-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Faculty of Pharmacy, Charles University, Hradec Králové, Czech Republic. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analgesics
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pharmacokinetics Animals Anticonvulsants / pharmacokinetics* Antipyrine / pharmacokinetics Blood Proteins / metabolism Chemistry, Physical Chromatography, High Pressure Liquid Female Perfusion Phenytoin / pharmacokinetics* Physicochemical Phenomena Placenta / metabolism* Pregnancy Protein Binding Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Analgesics; 0/Anticonvulsants; 0/Blood Proteins; 57-41-0/Phenytoin; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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