Document Detail


Phenytoin-induced thrombocytopenia.
MedLine Citation:
PMID:  3150279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 15-year-old boy developed thrombocytopenia and purpura two weeks after starting phenytoin therapy. The blood phenytoin level was in the toxic range. There was an increase in immature neutrophils but no abnormalities were present in other cell lines. Recovery was complete after drug therapy was discontinued. Thrombocytopenia is a rare isolated complication of phenytoin therapy. The probable autoimmune etiology distinguishes this syndrome from other phenytoin-induced blood dyscrasias.
Authors:
J J Brown; R W Chun
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  2     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:    1986 Mar-Apr
Date Detail:
Created Date:  1989-06-23     Completed Date:  1989-06-23     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Wisconsin School of Medicine, Madison 53792.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Epilepsy, Tonic-Clonic / drug therapy*
Humans
Male
Phenytoin / adverse effects*,  therapeutic use
Thrombocytopenia / chemically induced*
Chemical
Reg. No./Substance:
57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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