| Phenytoin-induced lymphocytic chemotaxis, angiogenesis and accelerated healing of decubitus ulcer in a patient with stroke. | |
| | |
MedLine Citation:
|
PMID: 15080024 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied the effect of topically applied phenytoin on the healing of a decubitus ulcer in the sacral region of an immobile patient with stroke. Another similar, but smaller, ulcer was treated with conventional treatment only and served as a control. The ulcers were measured once a week and biopsies were taken from the margins before, 1 week and 2 weeks after commencing treatment with phenytoin. Clinically, phenytoin substantially accelerated the rate of healing. Microscopic examination of the biopsies showed increased lymphocytic infiltration of the phenytoin-treated lesion. Anti-CD31 immunohistochemistry revealed dense CD31+ lymphocytic infiltration and increased angiogenesis only in the phenytoin-treated lesion. Our findings suggest that phenytoin enhances wound healing by stimulating lymphocytic chemotaxis and up-regulation of angiogenesis. |
| | |
Authors:
|
M Pitiakoudis; A Giatromanolaki; I Iliopoulos; A K Tsaroucha; C Simopoulos; C Piperidou |
Related Documents
:
|
2324974 - Review of metatarsal osteotomies for the treatment of neuropathic ulcerations. 1547084 - Limitations of subfascial ligation for refractory chronic venous stasis ulceration. 3885084 - Tripotassium dicitrato-bismuthate tablets v liquid in the treatment of duodenal ulcers. 1607464 - Pericapillary fibrin cuffs in venous ulceration. persistence with treatment and during ... 17636194 - Administration of recombinant activated factor vii (novoseven) in three cases of uncont... 18520504 - A comparative study of tissue glue and vicryl suture for closing limbal-conjunctival au... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: The Journal of international medical research Volume: 32 ISSN: 0300-0605 ISO Abbreviation: J. Int. Med. Res. Publication Date: 2004 Mar-Apr |
Date Detail:
|
Created Date: 2004-04-14 Completed Date: 2004-11-22 Revised Date: 2005-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0346411 Medline TA: J Int Med Res Country: England |
Other Details:
|
Languages: eng Pagination: 201-5 Citation Subset: IM |
Affiliation:
|
Second Department of Surgery, Medical School, Democritus University of Thrace, Alexandoupolis, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chemotaxis, Leukocyte
/
drug effects* Humans Immunohistochemistry Male Middle Aged Neovascularization, Physiologic / drug effects* Phenytoin / adverse effects, pharmacology, therapeutic use* Pressure Ulcer / physiopathology, therapy* Wound Healing / drug effects* |
| Chemical | |
Reg. No./Substance:
|
57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The efficacy and tolerability of barnidipine hydrochloride in Thai patients with hypertension.
Next Document: Clinical usefulness of doxazosin in patients with type 2 diabetes complicated by hypertension: effec...