Document Detail

Phenytoin elimination in newborns.
MedLine Citation:
PMID:  6681658     Owner:  NLM     Status:  MEDLINE    
We measured the apparent half-life (t50%) of phenytoin (PHT) 30 times in 16 infants (aged 2 to 36 days) who had seizures. During the first week of life, the t50%s ranged from 6 to 140 hours. After the first week, the concentration dependence of PHT elimination was demonstrated; the t50% was related to the initial concentration (Ci). The t50% also decreased with postnatal age. Controlling for a Ci of 18 mg per liter, the average t50% decreased threefold between the first (57.3 +/- 48.2 hours) and fourth weeks (19.7 +/- 1.31). In newborns, both age-related changes and the concentration dependence of PHT elimination can cause PHT levels to decrease when constant doses are given.
B F Bourgeois; W E Dodson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  33     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  173-8     Citation Subset:  AIM; IM    
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MeSH Terms
Age Factors
Infant, Newborn
Infant, Newborn, Diseases / blood,  metabolism*
Phenytoin / blood,  metabolism*
Seizures / blood,  drug therapy,  metabolism*
Grant Support
Reg. No./Substance:

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