| Phenytoin elimination after intoxication during long-term treatment. | |
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MedLine Citation:
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PMID: 6813663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Because of the saturable nature of phenytoin metabolism, intoxication due to overdosage with this drug occurs relatively frequently. The present paper reports on a systematic study of phenytoin elimination in six patients with clinical signs of overdosage and with initial serum phenytoin levels well above the normal therapeutic range (40 mumol/L to 80 mumol/L). On the basis of data obtained, it is recommended that, when a patient presents with symptoms of phenytoin intoxiation, an initial serum phenytoin level should be determined. If this exceeds 130 mumol/L, the drug should be withdrawn for a period of 72 to 84 hours, then the administration should be recommenced at a lower dose. |
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Authors:
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J Baird-Lambert; E Jäger-Roman; N Buchanan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Medical journal of Australia Volume: 2 ISSN: 0025-729X ISO Abbreviation: Med. J. Aust. Publication Date: 1982 Sep |
Date Detail:
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Created Date: 1982-12-18 Completed Date: 1982-12-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400714 Medline TA: Med J Aust Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 228-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Epilepsy / drug therapy Female Humans Long-Term Care Middle Aged Phenytoin / blood, poisoning* |
| Chemical | |
Reg. No./Substance:
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57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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