Document Detail


Phenylpyrazole insecticide fipronil induces male infertility in the estuarine meiobenthic crustacean Amphiascus tenuiremis.
MedLine Citation:
PMID:  14750729     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Copepods are the most abundant arthropods on earth and are often the most important secondary producers in estuarine/marine food webs. The new GABA (gamma-aminobutyric acid)-disrupting insecticide fipronil (FP) induces unique sex-specific reproductive dysfunction in male meiobenthic copepods, leading to trans-generational population depression at environmentally realistic concentrations (0.63 microg/L). Using a newly developed 96-well microplate lifecycle bioassay, more than 700 individual Stage-I juveniles were reared to adulthood in as short as 12 days in only 200 microL of control (CTL) or 0.63 microg-FP/L seawater solution. Individual virgin male: female pairs were then cross-mated for all possible combinations within and across rearing treatments and allowed to mate for an additional 12 days in CTL or 0.63 microg-FP/L solution. FP at 0.63 microg/L caused no significant lethality to any mating combinations but evoked 73% or 89% inhibition of reproduction when FP-reared males were mated with either a control- or FP-reared female in FP solution, respectively. In contrast, when CTL-reared males were mated with FP-reared females in FP solution, there was no difference in reproductive success compared to FP-free controls. When FP-reared males were mated with either female group in FP-free solution, these mating pairs displayed a 3-day delay in time to brood sac extrusion but ultimately did reproduce. As fipronil (1) has a high K(ow), (2) is persistent in sediments where meiobenthic copepods live, and (3) has been detected in estuarine waters >0.7 microg/L, it may pose high risk to copepod production in estuarine systems.
Authors:
Tawnya L Cary; G Thomas Chandler; David C Volz; Spencer S Walse; John L Ferry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  38     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-30     Completed Date:  2004-04-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-8     Citation Subset:  IM    
Affiliation:
Department of Environmental Health Sciences, Norman J. Arnold School of Public Health, University of South Carolina, Columbia, South Carolina 29208, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Assay
Copepoda / physiology*
Female
Infertility, Male / chemically induced*,  veterinary*
Insecticides / toxicity*
Male
Population Dynamics
Pyrazoles / toxicity*
Risk Assessment
Water Pollutants, Chemical / toxicity*
Chemical
Reg. No./Substance:
0/Insecticides; 0/Pyrazoles; 0/Water Pollutants, Chemical; 120068-37-3/fipronil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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