Document Detail

Phenylpropanolamine-induced psychosis. Potential predisposing factors.
MedLine Citation:
PMID:  7995508     Owner:  NLM     Status:  MEDLINE    
Phenylpropanolamine (PPA) is a sympathomimetic drug contained in numerous over-the-counter and prescription decongestants and appetite suppressants. A range of adverse effects have been reported, including neuropsychiatric reactions in patients known to be taking recommended doses. Given that psychiatric symptoms are not included in the manufacturer's lists of adverse drug reactions, the incidence may be significantly higher. We report a cae of paranoid psychosis following use of a decongestant containing PPA and summarize the case report literature of psychiatric adverse effects to PPA in which doses were known and stated to be within recommended guidelines. A pattern of possible risk factors emerges from these reports. These may include 1) symptoms or history of mood spectrum disorder, 2) history of psychosis, 3) female sex, 4) family history of psychiatric disorder. The possibility that a higher incidence of adverse events occurs in a vulnerable population has not been systematically addressed, and seems called for. We recommend that physicians specifically inquire about patients' use of decongestants and diet aids. In half of the above cases, symptoms resolved without the use of antipsychotics.
R D Marshall; C J Douglas
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  General hospital psychiatry     Volume:  16     ISSN:  0163-8343     ISO Abbreviation:  Gen Hosp Psychiatry     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-17     Completed Date:  1995-01-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905527     Medline TA:  Gen Hosp Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  358-60     Citation Subset:  IM; X    
New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, NY 10032.
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MeSH Terms
Dose-Response Relationship, Drug
Paranoid Disorders / chemically induced,  genetics,  psychology
Phenylpropanolamine / administration & dosage,  adverse effects*
Risk Factors
Sinusitis / drug therapy
Substance-Related Disorders / etiology*,  genetics,  psychology
Reg. No./Substance:
Comment In:
Gen Hosp Psychiatry. 1995 Nov;17(6):457-8   [PMID:  8714809 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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