Document Detail

Phenylethylmalonamide in essential tremor. A double-blind controlled study.
MedLine Citation:
PMID:  7031184     Owner:  NLM     Status:  MEDLINE    
A randomised double-blind placebo-controlled trial of phenylethylmalonamide, the major metabolite of primidone was performed in eight patients with essential tremor. Phenylethylmalonamide was given in a daily dose of 400 mg for one week and 800 mg for a second week. The compound had no statistically significant effect on the amplitude of tremor assessed by an accelerometric method, tests of performance, clinical evaluation and patient self assessment. No side effects occurred. Serum levels of phenylethylmalonamide on a daily dose of 400 mg were 11-27 micrograms/ml and on 800 mg daily were 16-48.5 micrograms/ml.
S Calzetti; L J Findley; F Pisani; A Richens
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of neurology, neurosurgery, and psychiatry     Volume:  44     ISSN:  0022-3050     ISO Abbreviation:  J. Neurol. Neurosurg. Psychiatr.     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-02-25     Completed Date:  1982-02-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985191R     Medline TA:  J Neurol Neurosurg Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  932-4     Citation Subset:  IM    
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Malonates / therapeutic use*
Middle Aged
Phenylethylmalonamide / administration & dosage,  blood,  therapeutic use*
Random Allocation
Tremor / drug therapy*
Reg. No./Substance:
0/Malonates; 7206-76-0/Phenylethylmalonamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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