Document Detail

Phenylethyl butyrate enhances the potency of second-line drugs against clinical isolates of Mycobacterium tuberculosis.
MedLine Citation:
PMID:  22106218     Owner:  NLM     Status:  MEDLINE    
Ethionamide (ETH) is a second-line drug for the treatment of tuberculosis. As a prodrug, ETH has to be activated by EthA. ethA is controlled by its repressor EthR. 2-Phenylethyl-butyrate (2-PEB) inhibits EthR binding, enhances expression of EthA, and thereby enhances the growth-inhibitory effects of ethionamide, isoxyl, and thiacetazone in Mycobacterium tuberculosis strains with resistance to ETH due to inhA promoter mutations but not ethA mutations.
Thomas Grau; Petra Selchow; Marcel Tigges; Reto Burri; Marc Gitzinger; Erik C Böttger; Martin Fussenegger; Peter Sander
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-11-21
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  56     ISSN:  1098-6596     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-25     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1142-5     Citation Subset:  IM    
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
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MeSH Terms
Antitubercular Agents / pharmacology*
Bacterial Proteins / drug effects,  genetics,  metabolism
Butyrates / chemistry,  pharmacology*
Drug Resistance, Multiple, Bacterial
Drug Synergism
Ethionamide / pharmacology*
Gene Expression Regulation, Bacterial
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*,  growth & development,  isolation & purification
Oxidoreductases / genetics
Oxygenases / drug effects,  genetics,  metabolism
Phenylthiourea / analogs & derivatives*,  pharmacology
Thioacetazone / pharmacology*
Reg. No./Substance:
0/Antitubercular Agents; 0/Bacterial Proteins; 0/Butyrates; 0/etaA protein, Mycobacterium tuberculosis; 103-85-5/Phenylthiourea; 104-06-3/Thioacetazone; 43M23X81Y2/thiocarlide; 536-33-4/Ethionamide; EC 1.-/Oxidoreductases; EC 1.13.-/Oxygenases; EC protein, Mycobacterium

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