Document Detail


Phenylephrine-induced hypertension during transient middle cerebral artery occlusion alleviates ischemic brain injury in spontaneously hypertensive rats.
MedLine Citation:
PMID:  22954904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Arterial hypertension is a major risk factor for ischemic stroke. However, the management of preexisting hypertension is still controversial in the treatment of acute stroke in hypertensive patients. The present study evaluates the influence of preserving hypertension during focal cerebral ischemia on stroke outcome in a rat model of chronic hypertension, the spontaneously hypertensive rats (SHR). Focal cerebral ischemia was induced by transient (1h) occlusion of the middle cerebral artery, during which mean arterial blood pressure was maintained at normotension (110-120mm Hg, group 1, n=6) or hypertension (160-170mm Hg, group 2, n=6) using phenylephrine. T2-, diffusion- and perfusion-weighted MRI were performed serially at five different time points: before and during ischemia, and at 1, 4 and 7 days after ischemia. Lesion volume and brain edema were estimated from apparent diffusion coefficient maps and T2-weighted images. Regional cerebral blood flow (rCBF) was measured within and outside the perfusion deficient lesion and in the corresponding regions of the contralesional hemisphere. Neurological deficits were evaluated after reperfusion. Infarct volume, edema, and neurological deficits were significantly reduced in group 2 vs. group 1. In addition, higher values and rapid restoration of rCBF were observed in group 2, while rCBF in both hemispheres was significantly decreased in group 1. Maintaining preexisting hypertension alleviates ischemic brain injury in SHR by increasing collateral circulation to the ischemic region and allowing rapid restoration of rCBF. The data suggest that maintaining preexisting hypertension is a valuable approach to managing hypertensive patients suffering from acute ischemic stroke.
Authors:
Byeong-Teck Kang; Renata F Leoni; Dong-Eog Kim; Afonso C Silva
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Publication Detail:
Type:  Journal Article     Date:  2012-08-29
Journal Detail:
Title:  Brain research     Volume:  1477     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-02-27     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Affiliation:
Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1065, USA.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Analysis of Variance
Animals
Blood Pressure / drug effects
Brain Edema / etiology,  physiopathology
Brain Injuries / etiology*,  therapy*
Cerebrovascular Circulation
Disease Models, Animal
Hypertension / chemically induced*
Infarction, Middle Cerebral Artery / complications*
Magnetic Resonance Imaging
Male
Neurologic Examination
Phenylephrine / toxicity*
Rats
Rats, Inbred SHR
Reperfusion Injury / therapy
Statistics, Nonparametric
Time Factors
Vasoconstrictor Agents / toxicity*
Grant Support
ID/Acronym/Agency:
Z99 NS999999/NS/NINDS NIH HHS; ZIA NS003012-06/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Vasoconstrictor Agents; 59-42-7/Phenylephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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