Document Detail

Phenylephrine-induced hypertension during transient middle cerebral artery occlusion alleviates ischemic brain injury in spontaneously hypertensive rats.
MedLine Citation:
PMID:  22954904     Owner:  NLM     Status:  MEDLINE    
Arterial hypertension is a major risk factor for ischemic stroke. However, the management of preexisting hypertension is still controversial in the treatment of acute stroke in hypertensive patients. The present study evaluates the influence of preserving hypertension during focal cerebral ischemia on stroke outcome in a rat model of chronic hypertension, the spontaneously hypertensive rats (SHR). Focal cerebral ischemia was induced by transient (1h) occlusion of the middle cerebral artery, during which mean arterial blood pressure was maintained at normotension (110-120mm Hg, group 1, n=6) or hypertension (160-170mm Hg, group 2, n=6) using phenylephrine. T2-, diffusion- and perfusion-weighted MRI were performed serially at five different time points: before and during ischemia, and at 1, 4 and 7 days after ischemia. Lesion volume and brain edema were estimated from apparent diffusion coefficient maps and T2-weighted images. Regional cerebral blood flow (rCBF) was measured within and outside the perfusion deficient lesion and in the corresponding regions of the contralesional hemisphere. Neurological deficits were evaluated after reperfusion. Infarct volume, edema, and neurological deficits were significantly reduced in group 2 vs. group 1. In addition, higher values and rapid restoration of rCBF were observed in group 2, while rCBF in both hemispheres was significantly decreased in group 1. Maintaining preexisting hypertension alleviates ischemic brain injury in SHR by increasing collateral circulation to the ischemic region and allowing rapid restoration of rCBF. The data suggest that maintaining preexisting hypertension is a valuable approach to managing hypertensive patients suffering from acute ischemic stroke.
Byeong-Teck Kang; Renata F Leoni; Dong-Eog Kim; Afonso C Silva
Related Documents :
7241254 - Evaluation of the nasa/jsc blood pressure screening clinic.
8489364 - Electronic pressure algometry of deep pain in healthy volunteers.
22743154 - Role of cuneiform nucleus in regulation of sympathetic vasomotor tone in rats.
20694934 - Examination of adolescents' screen time and physical fitness as independent correlates ...
18525384 - The acute effect of green tea consumption on endothelial function in healthy individuals.
11004064 - A pilot study of left tracheal pulse oximetry.
Publication Detail:
Type:  Journal Article     Date:  2012-08-29
Journal Detail:
Title:  Brain research     Volume:  1477     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-24     Completed Date:  2013-02-27     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  83-91     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Cerebral Microcirculation Unit, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892-1065, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Analysis of Variance
Blood Pressure / drug effects
Brain Edema / etiology,  physiopathology
Brain Injuries / etiology*,  therapy*
Cerebrovascular Circulation
Disease Models, Animal
Hypertension / chemically induced*
Infarction, Middle Cerebral Artery / complications*
Magnetic Resonance Imaging
Neurologic Examination
Phenylephrine / toxicity*
Rats, Inbred SHR
Reperfusion Injury / therapy
Statistics, Nonparametric
Time Factors
Vasoconstrictor Agents / toxicity*
Grant Support
Reg. No./Substance:
0/Vasoconstrictor Agents; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Sex differences in white matter development during adolescence: a DTI study.
Next Document:  One-year, randomized, open trial comparing olanzapine, quetiapine, risperidone and ziprasidone effec...