Document Detail


Phenylephrine-induced antinociception: investigations of potential neural and endocrine bases.
MedLine Citation:
PMID:  2271928     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute hypertensive states can produce antinociception, largely via unknown mechanisms. The aim of the present series of experiments was to examine potential hormonal and neural bases of analgesia induced by i.v. infusion of the pressor (hypertensive) agent phenylephrine. All rats were implanted with right jugular and left carotid cannulae for phenylephrine infusion and blood pressure/heart rate monitoring, respectively, and were tested approximately 24 h later in the unanesthetized state. The tail-flick test was used to measure responsivity prior to, during, and after phenylephrine infusion. Potential adrenal and pituitary contributions to phenylephrine-induced antinociception were examined, respectively, by physical disruption of adrenal blood flow and pharmacological suppression of pituitary activation. Acute block of all adrenal hormones, via closure at the time of testing of pre-implanted adrenal ligatures, did not block phenylephrine antinociception. However, pharmacological suppression of pituitary activation via pretreatment with the synthetic glucocorticoid dexamethasone abolished phenylephrine antinociception. Intriguingly, dexamethasone had no noticeable effect on urination prior to phenylephrine administration, yet only dexamethasone-treated rats exhibited copious urination during phenylephrine infusion. This suggests that the hypertensive agent phenylephrine releases vasopressin from the posterior pituitary terminals of the paraventricular hypothalamus (PVH) in a dexamethasone-suppressible manner, possibly via the known baroreceptor-nucleus tractus solitarius (NTS)-PVH link. Since (1) bilateral lesions of the spinal cord dorsolateral funiculus (DLF) were shown in the current study to abolish phenylephrine antinociception, (2) PVH is known to send vasopressinergic projections to the spinal cord via the DLF, and (3) intrathecal vasopressin produces antinociception via V1-like vasopressin receptors, the effect of an intrathecal V1 vasopressin antagonist was tested on phenylephrine-induced antinociception. The V1 vasopressin antagonist blocked phenylephrine antinociception, suggesting that phenylephrine antinociception may be mediated by a baroreceptor-NTS-PVH-DLF circuit leading to vasopressin release at spinal levels.
Authors:
L R Watkins; C L Thurston; M Fleshner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  528     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1990 Oct 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-84     Citation Subset:  IM    
Affiliation:
Department of Psychology, University of Colorado, Boulder 80309.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / physiology
Analgesics*
Animals
Arginine Vasopressin / analogs & derivatives,  pharmacology
Blood Pressure / drug effects
Corticosterone / analysis
Dexamethasone / pharmacology
Endocrine Glands / drug effects*
Heart Rate / drug effects
Male
Monitoring, Physiologic
Naloxone / pharmacology
Naltrexone / pharmacology
Neural Pathways / drug effects*
Phenylephrine / pharmacology*
Rats
Rats, Inbred Strains
Spinal Cord / physiology
Vasopressins / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
NS-20037/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics; 11000-17-2/Vasopressins; 113-79-1/Arginine Vasopressin; 16590-41-3/Naltrexone; 465-65-6/Naloxone; 50-02-2/Dexamethasone; 50-22-6/Corticosterone; 59-42-7/Phenylephrine; 81131-88-6/argipressin, 1-(beta-mercapto-beta,beta-diethylpropionic acid)-

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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