Document Detail

Phenylephrine eye drops in ophthalmic surgery--a clinical study on cardiovascular effects.
MedLine Citation:
PMID:  8090095     Owner:  NLM     Status:  MEDLINE    
Phenylephrine in concentrations of either 2.5% or 10% is widely used as a mydriatic agent in ophthalmic surgery. Its potential cardiovascular effects are seldom recorded as ophthalmic surgery is not usually monitored by an anaesthetist. A prospective randomised double blind study was carried out in 89 consecutive cases of uncomplicated cataract surgery in the presence of an anaesthesiologist ensuring the continuous monitoring of blood pressure, heart rate, electrocardiography and pulse oximetry. All these patients were given a drop of either normal saline, 2.5% or 10% phenylephrine in addition to mydriacyl prior to surgery. Blood pressure readings were found to be significantly higher in non-hypertensive patients receiving phenylephrine at the start of the operation and at five, 10, 15 and 20 minutes intra-operatively and the first three hours post-operatively. Blood pressure readings in hypertensive patients, on the other hand, were also found to increase after phenylephrine administration, though not statistically significant. 10.3% of the 10% phenylephrine group and 3% of the 2.5% phenylephrine group required intraoperative intravenous hypotensive agent to control the blood pressure. There were no arrhythmias or ischaemic changes observed intraoperatively. None of the patients complained of palpitation, headache or chest discomfort. There was no oxygen desaturation observed. We concluded that significant hypertensive effects can arise after phenylephrine eye drop administration. Hence, it should be used cautiously with intraoperative monitoring of the cardiovascular status during cataract surgery.
K W Chin; N M Law; M K Chin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Medical journal of Malaysia     Volume:  49     ISSN:  0300-5283     ISO Abbreviation:  Med. J. Malaysia     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-20     Completed Date:  1994-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361547     Medline TA:  Med J Malaysia     Country:  MALAYSIA    
Other Details:
Languages:  eng     Pagination:  158-63     Citation Subset:  IM    
Department of Anaesthesia, Tan Tock Seng Hospital, Singapore.
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MeSH Terms
Aged, 80 and over
Blood Pressure / drug effects*
Cataract Extraction*
Double-Blind Method
Middle Aged
Ophthalmic Solutions
Phenylephrine / administration & dosage,  pharmacology*
Prospective Studies
Reg. No./Substance:
0/Ophthalmic Solutions; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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