| Phenthoate metabolites in human poisoning. | |
| | |
MedLine Citation:
|
PMID: 8308949 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Five metabolites were detected in the plasma and urine of a patient following ingestion of the organophosphate insecticide, phenthoate. Intact phenthoate was detected only in gastric lavage fluid. After methylation of acidic extracts of plasma and urine, phenthoate acid, demethyl phenthoate, demethyl phenthoate oxon acid, demethyl phenthoate S-isomer, and demethyl phenthoate acid S-isomer were identified with synthesized phenthoate analogues by gas chromatography and gas chromatograph-mass spectrometry. The main metabolites were phenthoate acid and demethyl phenthoate oxon acid. Although demethyl phenthoate oxon acid was a significant metabolite, no phenthoate oxon, phenthoate oxon acid or demethyl phenthoate oxon were detected. If the oxon was formed in the patient, it may have been rapidly degraded by carboxylesterase or glutathione transferase to demethyl phenthoate oxon acid. |
| | |
Authors:
|
S Kawabata; M Hayasaka; H Hayashi; M Sakata; Y Hatakeyama; N Ogura |
Related Documents
:
|
21303379 - The n-terminal amino acid of apolipoprotein d is putatively covalently bound to 3-hydro... 1303649 - Screening for neuroblastoma in the north of england. 17664249 - Identification of new flavone-8-acetic acid metabolites using mouse microsomes and comp... 7703369 - Synthesis and characterization of n-acetyl-l-cysteine s-conjugates of butadiene monoxid... 6186299 - Relationships in healthy volunteers between secretion of monoamine metabolites in urine... 23105689 - Caprine cardiac sarcoplasmic reticulum: effect of simulated ischemia on membrane struct... 11996569 - Hybrid dendritic-linear polyester-ethers for in situ photopolymerization. 3095629 - Purification and characterization of metallothionein from liver of cadmium exposed rhes... 15066659 - Evaluation of the antibacterial efficacy of diesters of azelaic acid. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of toxicology. Clinical toxicology Volume: 32 ISSN: 0731-3810 ISO Abbreviation: J. Toxicol. Clin. Toxicol. Publication Date: 1994 |
Date Detail:
|
Created Date: 1994-03-16 Completed Date: 1994-03-16 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8213460 Medline TA: J Toxicol Clin Toxicol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 49-60 Citation Subset: AIM; IM |
Affiliation:
|
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Ishikari, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chromatography, Gas Humans Insecticides / blood, metabolism*, poisoning*, urine Male Middle Aged Organothiophosphorus Compounds / blood, metabolism*, poisoning*, urine Poisoning / diagnosis |
| Chemical | |
Reg. No./Substance:
|
0/Insecticides; 0/Organothiophosphorus Compounds; 2597-03-7/phenthoate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypokalemia, hyperglycemia and plasma catecholamine activity after severe theophylline intoxication.
Next Document: Organophosphate poisoning: peripheral vascular resistance--a measure of adequate atropinization.