Document Detail


Phenthoate metabolites in human poisoning.
MedLine Citation:
PMID:  8308949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five metabolites were detected in the plasma and urine of a patient following ingestion of the organophosphate insecticide, phenthoate. Intact phenthoate was detected only in gastric lavage fluid. After methylation of acidic extracts of plasma and urine, phenthoate acid, demethyl phenthoate, demethyl phenthoate oxon acid, demethyl phenthoate S-isomer, and demethyl phenthoate acid S-isomer were identified with synthesized phenthoate analogues by gas chromatography and gas chromatograph-mass spectrometry. The main metabolites were phenthoate acid and demethyl phenthoate oxon acid. Although demethyl phenthoate oxon acid was a significant metabolite, no phenthoate oxon, phenthoate oxon acid or demethyl phenthoate oxon were detected. If the oxon was formed in the patient, it may have been rapidly degraded by carboxylesterase or glutathione transferase to demethyl phenthoate oxon acid.
Authors:
S Kawabata; M Hayasaka; H Hayashi; M Sakata; Y Hatakeyama; N Ogura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of toxicology. Clinical toxicology     Volume:  32     ISSN:  0731-3810     ISO Abbreviation:  J. Toxicol. Clin. Toxicol.     Publication Date:  1994  
Date Detail:
Created Date:  1994-03-16     Completed Date:  1994-03-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8213460     Medline TA:  J Toxicol Clin Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  49-60     Citation Subset:  AIM; IM    
Affiliation:
Faculty of Pharmaceutical Sciences, Higashi-Nippon-Gakuen University, Ishikari, Japan.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, Gas
Humans
Insecticides / blood,  metabolism*,  poisoning*,  urine
Male
Middle Aged
Organothiophosphorus Compounds / blood,  metabolism*,  poisoning*,  urine
Poisoning / diagnosis
Chemical
Reg. No./Substance:
0/Insecticides; 0/Organothiophosphorus Compounds; 2597-03-7/phenthoate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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