Document Detail


Phentermine and topiramate extended release (Qsymia™): first global approval.
MedLine Citation:
PMID:  23039320     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vivus' proprietary oral capsule containing phentermine and extended-release (ER) topiramate has been approved in the US for the treatment of obesity. Phentermine is an appetite suppressant, while topiramate is an anti-epileptic medication. The once-daily formulation, known as Qsymia™, is designed to produce weight loss by decreasing appetite and increasing satiety. The product is also in clinical development for sleep apnoea syndrome and type 2 diabetes mellitus. This article summarizes the milestones in the development of phentermine/topiramate ER leading to this first approval for obesity.
Authors:
Fiona Cameron; Glenn Whiteside; Kate McKeage
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs     Volume:  72     ISSN:  0012-6667     ISO Abbreviation:  Drugs     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-11     Revised Date:  2013-08-21    
Medline Journal Info:
Nlm Unique ID:  7600076     Medline TA:  Drugs     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  2033-42     Citation Subset:  IM    
Affiliation:
Adis R&D Insight, Springer Healthcare, Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Anti-Obesity Agents / administration & dosage*
Appetite Depressants / administration & dosage*
Clinical Trials as Topic
Delayed-Action Preparations
Fructose / administration & dosage,  analogs & derivatives*
Humans
Obesity / drug therapy
Phentermine / administration & dosage*
Randomized Controlled Trials as Topic
Chemical
Reg. No./Substance:
0/Anti-Obesity Agents; 0/Appetite Depressants; 0/Delayed-Action Preparations; 0H73WJJ391/topiramate; 122-09-8/Phentermine; 30237-26-4/Fructose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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