Document Detail

Phenprocoumon therapy during pregnancy: case report and comparison of the teratogenic risk of different coumarin derivatives.
MedLine Citation:
PMID:  8147045     Owner:  NLM     Status:  MEDLINE    
The case report is about an infant suffering from coumarin embryopathy and coumarin syndrome after its mother underwent phenprocoumon treatment (Marcumar, Falithrom) during pregnancy (until 26th week of gestation). Interestingly, a hearing disorder was diagnosed, which had never been described in context with this substance. The coumarin derivatives warfarin, acenocoumarol and phenoprocoumon were compared with regards to spontaneous abortion rate, perinatal mortality and teratogenic risk. Eye anomalies or malformations seem to appear only under warfarin treatment, whereas CNS-malformations are more frequent under phenprocoumon. As a consequence, phenprocoumon treatment of fertile women seems rather doubtful. Upon discovery of a pregnancy under coumarin treatment, vitamin K should immediately be substituted in order to minimize the risk of anomalies and malformation.
B C Gärtner; C B Seifert; D V Michalk; B Roth
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Zeitschrift für Geburtshilfe und Perinatologie     Volume:  197     ISSN:  0300-967X     ISO Abbreviation:  Z Geburtshilfe Perinatol     Publication Date:    1993 Nov-Dec
Date Detail:
Created Date:  1994-05-03     Completed Date:  1994-05-03     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0326205     Medline TA:  Z Geburtshilfe Perinatol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  262-5     Citation Subset:  IM    
Universitäts-Kinderklinik Köln.
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MeSH Terms
Abnormalities, Drug-Induced / etiology*
Abnormalities, Multiple / chemically induced
Coumarins / administration & dosage,  adverse effects*
Heart Valve Diseases / drug therapy*
Infant, Newborn
Intracranial Embolism and Thrombosis / drug therapy*
Phenprocoumon / administration & dosage,  adverse effects*
Pregnancy Complications, Cardiovascular / drug therapy*
Risk Factors
Reg. No./Substance:
0/Coumarins; 435-97-2/Phenprocoumon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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