| Phenotyping the right ventricle in patients with pulmonary hypertension. | |
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MedLine Citation:
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PMID: 20443908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Right ventricular (RV) failure is associated with poor outcomes in pulmonary hypertension (PH). We sought to phenotype the RV in PH patients with compensated and decompensated RV function by quantifying regional and global RV structural and functional changes. Twenty-two patients (age 51 +/- 11, 14 females, mean pulmonary artery (PA) pressure range 13-79 mmHg) underwent right heart catheterization, echocardiography, and ECG-gated multislice computed tomography of the chest. Patients were divided into three groups: Normal, PH with hemodynamically compensated, and decompensated RV function (PH-C and PH-D, respectively). RV wall thickness (WT) was measured at end-diastole (ED) and end-systole (ES) in three regions: infundibulum, lateral free wall, and inferior free wall. Globally, RV volumes progressively increased from Normal to PH-C to PH-D and RV ejection fraction decreased. Regionally, WT increased and fractional wall thickening (FWT) decreased in a spatially heterogeneous manner. Infundibular wall stress was elevated and FWT was lower regardless of the status of global RV function. In PH, there are significant phenotypic abnormalities in the RV even in the absence of overt hemodynamic RV decompensation. Regional changes in RV structure and function may be early markers of patients at risk for developing RV failure. |
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Authors:
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Marc A Simon; Christopher Deible; Michael A Mathier; Joan Lacomis; Orly Goitein; Sanjeev G Shroff; Michael R Pinsky |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and translational science Volume: 2 ISSN: 1752-8062 ISO Abbreviation: Clin Transl Sci Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2010-05-06 Completed Date: 2010-08-09 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 101474067 Medline TA: Clin Transl Sci Country: United States |
Other Details:
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Languages: eng Pagination: 294-9 Citation Subset: IM |
Affiliation:
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Cardiovascular Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. simonma@upmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Diastole Disease Progression Echocardiography / methods Female Heart Ventricles / pathology* Humans Hypertension, Pulmonary / pathology* Male Middle Aged Phenotype Pulmonary Artery / pathology Risk Systole Ventricular Function, Right |
| Grant Support | |
ID/Acronym/Agency:
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HL067181/HL/NHLBI NIH HHS; HL07820/HL/NHLBI NIH HHS; K24 HL067181-05/HL/NHLBI NIH HHS; K24 HL067181-10/HL/NHLBI NIH HHS; KL2RR024154/RR/NCRR NIH HHS; L30 HL078435-03A1/HL/NHLBI NIH HHS; T32 HL007820-10/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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