Document Detail

Phenotypical evidence for a gender difference in cardiac norepinephrine transporter function.
MedLine Citation:
PMID:  14726430     Owner:  NLM     Status:  MEDLINE    
Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations. Clinical observations in orthostatic intolerance patients suggest a gender difference in NET function. We compared the cardiovascular response to selective NET inhibition with reboxetine between 12 healthy men and 12 age-matched women. Finger blood pressure, brachial blood pressure, and heart rate were measured. The subjects underwent cardiovascular autonomic reflex testing and a graded head-up tilt test. In a separate study, we applied incremental concentrations of tyramine and isoproterenol through subcutaneous microdialysis catheters in eight men and in eight women. NET inhibition elicited a threefold greater increase in supine blood pressure in men than women (P < 0.05). The pressor response was driven by an increased cardiac output. The orthostatic heart rate increase during NET inhibition was greater in men than women (56 +/- 5 beats/min in men, 42 +/- 4 beats/min in women, P < 0.001). In contrast, NET inhibition resulted in a similar suppression in the cold pressor and handgrip response, low-frequency blood pressure oscillations, and venous norepinephrine in the supine position. Men and women were similarly sensitive to the lipolytic effect of isoproterenol and tyramine. We conclude that NET inhibition results in more pronounced changes in cardiac regulation in men than women. Our observations suggest that the NET contribution to cardiac norepinephrine turnover may be decreased in women. The gender difference in NET function may not be expressed in tissues that are less NET dependent than the heart.
Christoph Schroeder; Frauke Adams; Michael Boschmann; Jens Tank; Sebastian Haertter; Andre Diedrich; Italo Biaggioni; Friedrich C Luft; Jens Jordan
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-01-15
Journal Detail:
Title:  American journal of physiology. Regulatory, integrative and comparative physiology     Volume:  286     ISSN:  0363-6119     ISO Abbreviation:  Am. J. Physiol. Regul. Integr. Comp. Physiol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-07     Completed Date:  2004-05-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100901230     Medline TA:  Am J Physiol Regul Integr Comp Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  R851-6     Citation Subset:  IM    
Franz Volhard Clinical Research Center, Haus 129, Medical Faculty of the Charité-Campus Buch, Wiltbergstrasse 50, 13125 Berlin, Germany.
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MeSH Terms
Adipose Tissue / innervation,  physiology
Adrenergic Uptake Inhibitors / administration & dosage,  blood
Autonomic Nervous System / physiology
Baroreflex / physiology
Blood Pressure / physiology
Cardiac Output / drug effects,  physiology
Heart Rate / drug effects,  physiology
Morpholines / administration & dosage,  blood
Myocardium / metabolism*
Norepinephrine / metabolism*
Norepinephrine Plasma Membrane Transport Proteins
Posture / physiology
Reflex / physiology
Sex Characteristics*
Symporters / antagonists & inhibitors,  metabolism*
Reg. No./Substance:
0/Adrenergic Uptake Inhibitors; 0/Morpholines; 0/Norepinephrine Plasma Membrane Transport Proteins; 0/SLC6A2 protein, human; 0/Symporters; 51-41-2/Norepinephrine; 98769-81-4/reboxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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