Document Detail

Phenotypical characteristics of the immune cells in allergic contact dermatitis, atopic dermatitis and pityriasis rosea.
MedLine Citation:
PMID:  18798012     Owner:  NLM     Status:  MEDLINE    
Allergic contact dermatitis (ACD) is a cell-mediated, delayed type IV immunologic reaction. Atopic dermatitis (AD) is a chronic inflammatory skin disease that results from a complex interaction between immunologic, genetic, and environmental factors. Pityriasis rosea (PR) is a self-limited eruption of unknown etiology. Immune cell infiltrate is a constant feature in the inflammatory skin diseases. Here, we performed phenotypical characterization of the immune cells in ACD, AD and PR (ten cases each). We performed immunohistochemical stains for B cells (CD20), T cells (CD3), histiocytes (CD68) and T cells with cytotoxic activity (granzyme-B). The data were compared with findings in 20 specimens of normal skin. The results were scored as mean values of positively stained immune cells. Immunohistochemistry showed significantly high counts of immune cells in lesional skin (ACD, AD and PR) compared to the normal one (p < 0.05). In the lesional skin, the immune cells were composed predominantly of CD3(+) T lymphocytes and CD68(+) cells (histiocytes). Some of the CD3(+) cells were granzyme B(+). The counts of some immune cells (CD3(+) and CD68(+)) were high in ACD compared to AD and PR. The counts of CD20(+) and granzyme B(+) cells were high in PR compared to ACD and AD. However, these differences did not reach the level of statistical significance. The present data describe the profile of the immune cell infiltrate in AD, ACD and PR. The cell-mediated immunity seems to have critical role in the development of these lesions.
Mahmoud Rezk A Hussein; Wafaa M Abdel-Magid; Ramadan Saleh; Essam Nada
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-09-17
Journal Detail:
Title:  Pathology oncology research : POR     Volume:  15     ISSN:  1219-4956     ISO Abbreviation:  Pathol. Oncol. Res.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706087     Medline TA:  Pathol Oncol Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  73-9     Citation Subset:  IM    
Department of Pathology, Assuit University Hospitals, Assuit University, Assuit, Egypt.
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MeSH Terms
Case-Control Studies
Dermatitis, Allergic Contact / immunology*,  pathology
Dermatitis, Atopic / immunology*,  pathology
Immunity, Cellular / physiology*
Immunoenzyme Techniques
Pityriasis Rosea / immunology*,  pathology
Skin / immunology,  pathology
T-Lymphocytes / immunology*,  pathology

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