Document Detail


Phenotypic reversion induced by anthracyclines in ras oncogene-expressed cells; structure-activity relationships.
MedLine Citation:
PMID:  8069262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several antitumor anthracyclines, including those in preclinical stages, were examined for their action in reversing tumorous phenotypes of H- or K-ras 3T3 cells (NIH3T3 cells transformed by human H- or K-ras oncogene) into normal phenotypes, such as flattened cell morphology, anchorage dependent cell growth, etc. (referred to as anti-ras activity). The study elucidated relationships between the chemical structure of anthracyclines and the anti-ras activity. The human tumor cell line T24, which has a mutated H-ras gene, responded to the anthracyclines, as did K- or H-ras 3T3 cells, in respect to the phenotypic alterations. Pirarubicin was more than 4 times as active as aclarubicin in inhibiting the growth of solid tumors of K-ras 3T3 cells in nude mice, possibly reflecting a difference in anti-ras activity between the two antibiotics.
Authors:
T Kanbe; K S Tsuchiya; M Hori; H Ekimoto; Y Takahashi; T Takeuchi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  17     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-09-26     Completed Date:  1994-09-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  527-30     Citation Subset:  IM    
Affiliation:
Showa College of Pharmaceutical Sciences, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
3T3 Cells
Animals
Antibiotics, Antineoplastic / pharmacology*
Cell Division / drug effects
Cell Line, Transformed
Genes, ras*
Humans
Mice
Mice, Nude
Neoplasms, Experimental / pathology*
Phenotype
Structure-Activity Relationship
Urinary Bladder Neoplasms / pathology
Chemical
Reg. No./Substance:
0/Antibiotics, Antineoplastic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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