| Phenotypic predictors of response to simvastatin therapy among African-Americans and Caucasians: the Cholesterol and Pharmacogenetics (CAP) Study. | |
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MedLine Citation:
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PMID: 16516587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although statins are effective lipid-lowering agents, the phenotypic and demographic predictors of such lowering have been less well examined. We enrolled 944 African-American and white men and women who completed an open-label, 6-week pharmacogenetics trial of 40 mg of simvastatin. The phenotypic and demographic variables were examined as predictors of the change in lipids and lipoproteins using linear regression analysis. On average, treatment with simvastatin lowered low-density lipoprotein (LDL) cholesterol by 54 mg/dl and increased high-density lipoprotein (HDL) cholesterol by 2 mg/dl. Compared with African-Americans, whites had a 3-mg/dl greater LDL reduction and a 1-mg/dl higher HDL elevation, independent of other variables, including baseline lipoprotein levels (p <0.01). Multivariate analyses revealed moderate subgroup differences, with older participants having a larger decrease in LDL cholesterol and apolipoprotein B levels compared with younger participants (p <0.001), women having larger increases in HDL than men (p <0.01), nonsmokers having larger decreases in LDL and triglyceride levels compared with smokers (p <0.05), those with hypertension having smaller decreases in apolipoprotein B than those without hypertension (p <0.05), and those with a larger waist circumference having a diminished lowering of triglycerides in response to treatment with simvastatin (p <0.01). In conclusion, treatment with simvastatin produced favorable lipid and lipoprotein changes among all participants. The magnitude of the lipid and lipoprotein responses, however, differed among participants according to a number of phenotypic and demographic characteristics. |
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Authors:
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Joel A Simon; Feng Lin; Stephen B Hulley; Patricia J Blanche; David Waters; Stephen Shiboski; Jerome I Rotter; Deborah A Nickerson; Huiying Yang; Mohammed Saad; Ronald M Krauss |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2006-01-27 |
Journal Detail:
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Title: The American journal of cardiology Volume: 97 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-04-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 843-50 Citation Subset: AIM; IM |
Affiliation:
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General Internal Medicine Section, Medical Service, Veterans Affairs Medical Center, San Francisco, California, USA. jasimon@itsa.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Americans* Age Factors Anticholesteremic Agents / administration & dosage, pharmacology, therapeutic use* Apolipoprotein A-I / blood, drug effects Apolipoproteins B / blood, drug effects Cholesterol, HDL / blood, drug effects Cholesterol, LDL / blood, drug effects Demography European Continental Ancestry Group* Female Humans Hypercholesterolemia / drug therapy*, ethnology, genetics Hypertension / complications Male Middle Aged Peptide Fragments / blood, drug effects Phenotype Sex Factors Simvastatin / administration & dosage, pharmacology, therapeutic use* Smoking / blood Treatment Outcome Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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U01-HL69757/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Peptide Fragments; 0/Triglycerides; 0/apolipoprotein B (3304-3317); 79902-63-9/Simvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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