| Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae. | |
MedLine Citation:
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PMID: 8319294 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary gene amplification, i.e., mutation from one gene copy to multiple gene copies per genome, is important in genomic evolution, as a means of producing anti-cancer drug resistance, and is associated with the progression of tumor malignancy. Primary amplification has not been studied in normal eukaryotic cells because amplifications are extremely rare in these cells. A system has been developed to phenotypically identify co-amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae and 21 independent spontaneous amplifications have been isolated. |
Authors:
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M J Dorsey; P Hoeh; C E Paquin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Current genetics Volume: 23 ISSN: 0172-8083 ISO Abbreviation: Curr. Genet. Publication Date: 1993 May-Jun |
Date Detail:
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Created Date: 1993-08-05 Completed Date: 1993-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004904 Medline TA: Curr Genet Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 392-6 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, University of Cincinnati, OH 45221-0006. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alcohol Dehydrogenase
/
genetics*,
metabolism Blotting, Southern Cloning, Molecular Gene Amplification* Genes, Fungal* Phenotype Saccharomyces cerevisiae / enzymology, genetics* |
| Chemical | |
Reg. No./Substance:
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EC 1.1.1.1/Alcohol Dehydrogenase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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