Document Detail

Phenotypic identification of amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae.
MedLine Citation:
PMID:  8319294     Owner:  NLM     Status:  MEDLINE    
Primary gene amplification, i.e., mutation from one gene copy to multiple gene copies per genome, is important in genomic evolution, as a means of producing anti-cancer drug resistance, and is associated with the progression of tumor malignancy. Primary amplification has not been studied in normal eukaryotic cells because amplifications are extremely rare in these cells. A system has been developed to phenotypically identify co-amplifications of the ADH4 and CUP1 genes of Saccharomyces cerevisiae and 21 independent spontaneous amplifications have been isolated.
M J Dorsey; P Hoeh; C E Paquin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Current genetics     Volume:  23     ISSN:  0172-8083     ISO Abbreviation:  Curr. Genet.     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-08-05     Completed Date:  1993-08-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004904     Medline TA:  Curr Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  392-6     Citation Subset:  IM    
Department of Biological Sciences, University of Cincinnati, OH 45221-0006.
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MeSH Terms
Alcohol Dehydrogenase / genetics*,  metabolism
Blotting, Southern
Cloning, Molecular
Gene Amplification*
Genes, Fungal*
Saccharomyces cerevisiae / enzymology,  genetics*
Reg. No./Substance:
EC Dehydrogenase

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