| Phenotypic and functional characteristics of human newborns' B lymphocytes. | |
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MedLine Citation:
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PMID: 1688576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been demonstrated two major facts concerning human newborns' B lymphocytes: 1) they differentiate poorly into Ig-producing cells and 2) they express CD5 and CD1c membrane proteins. We have further analyzed human newborns' B cell characteristics and found that approximately half of them express activation Ag, i.e., 4F2 and IL-2R, both associated in significant proportions with CD23 and Bac-1. These membrane Ag were found both on CD5(+) and CD5(-) B cells. Newborns' B cells do not exhibit other activation markers because they express surface IgD, and because their size, RNA, and DNA contents do not differ from those of adults' B cells, indicating that they are in the G0/G1 cell cycle phase. Newborns' B cell proliferation can be induced by rIL-2, rIL-4, low m.w. B cell growth factor, and by Staphylococcus aureus protein A. It is presently difficult to build a hypothesis accounting for all the specific findings made on newborns' B cells. It is not known for instance whether CD5(+) and (-) B cells belong to distinct subsets as suggested by the fluorescence intensity curve obtained with an anti-CD5 antibody or to distinct stages in a unique pattern of B cell maturation during fetal and newborn life. This may indicate that partially activated B cells actually produce natural polyspecific autoantibodies of the IgM isotype found in newborns' human serum. |
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Authors:
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A Durandy; L Thuillier; M Forveille; A Fischer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 144 ISSN: 0022-1767 ISO Abbreviation: J. Immunol. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-09 Completed Date: 1990-02-09 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 60-5 Citation Subset: AIM; IM |
Affiliation:
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INSERM U 132, Hôpital des Enfants Malades, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD
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analysis Antigens, CD5 Antigens, Differentiation / analysis B-Lymphocytes / cytology, immunology, physiology* Cell Differentiation Cell Membrane / immunology Flow Cytometry Humans Immunoglobulin D / analysis Infant, Newborn / immunology* Interleukin-2 / pharmacology Interleukin-4 / pharmacology Lymphocyte Activation / drug effects Receptors, Antigen, B-Cell / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/Antigens, CD5; 0/Antigens, Differentiation; 0/Immunoglobulin D; 0/Interleukin-2; 0/Receptors, Antigen, B-Cell; 207137-56-2/Interleukin-4 |
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