| Phenotypic enhancement of longevity by environmental urea in Drosophila melanogaster. | |
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MedLine Citation:
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PMID: 9415109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The phenotypic enhancement of longevity through a variety of environmental treatments, including dietary manipulations, has been observed in various species of animals, both vertebrate and invertebrate. Elucidating the mechanisms underlying such effects has provided insights into the physiological processes contributing to the determination of lifespan. Here, we report the enhancement of longevity in adult Drosophila melanogaster maintained on food supplemented with urea, a metabolic waste product occurring naturally in Drosophila cultures, especially at high larval densities. The impact of urea on longevity is shown to be through a decrease in the age-independent parameter (A) of the Gompertz equation, rather than the age-dependent parameter (alpha), which reflects the "rate of aging." We also present evidence suggesting that the urea-induced increase in longevity is mediated exclusively through a reduction in some aspect(s) of reproduction in adult flies maintained on urea-supplemented food. |
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Authors:
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A Joshi; J Shiotsugu; L D Mueller |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Experimental gerontology Volume: 31 ISSN: 0531-5565 ISO Abbreviation: Exp. Gerontol. Publication Date: 1996 Jul-Aug |
Date Detail:
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Created Date: 1998-01-15 Completed Date: 1998-01-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0047061 Medline TA: Exp Gerontol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 533-44 Citation Subset: IM |
Affiliation:
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Department of Ecology and Evolutionary Biology, University of California, Irvine 92717, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila melanogaster / physiology* Female Longevity / drug effects* Male Phenotype Urea / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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AG09970/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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57-13-6/Urea |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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