Document Detail


Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans.
MedLine Citation:
PMID:  18177873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To better understand the biology of tameness, i.e. tolerance of human presence and handling, we analyzed two lines of wild-derived rats (Rattus norvegicus) artificially selected for tameness and defensive aggression towards humans. In response to a gloved human hand, tame rats tolerated handling, whereas aggressive rats attacked. Cross-fostering showed that these behavioral differences are not caused by postnatal maternal effects. Tame rats were more active and explorative and exhibited fewer anxiety-related behaviors. They also had smaller adrenal glands, larger spleens and lower levels of serum corticosterone. Blood glucose levels were lower in tame rats, whereas the concentrations of nine amino acids were higher. In the brain, tame rats had lower serotonin and higher taurine levels than aggressive rats. Our findings reinforce the notion that tameness is correlated with differences in stress response and will facilitate future efforts to uncover the genetic basis for animal tameness.
Authors:
Frank W Albert; Olesya Shchepina; Christine Winter; Holger Römpler; Daniel Teupser; Rupert Palme; Uta Ceglarek; Jürgen Kratzsch; Reinhard Sohr; Lyudmila N Trut; Joachim Thiery; Rudolf Morgenstern; Irina Z Plyusnina; Torsten Schöneberg; Svante Pääbo
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-11-28
Journal Detail:
Title:  Hormones and behavior     Volume:  53     ISSN:  0018-506X     ISO Abbreviation:  Horm Behav     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-05-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  413-21     Citation Subset:  IM    
Affiliation:
Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany. falbert@eva.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological / physiology
Adrenal Glands / anatomy & histology
Aggression / physiology*
Amino Acids / metabolism
Analysis of Variance
Animals
Anxiety / blood*,  genetics,  psychology
Behavior, Animal / physiology*
Blood Glucose / genetics,  physiology
Brain / metabolism
Exploratory Behavior / physiology
Female
Handling (Psychology)
Male
Organ Size
Phenotype
Rats
Rats, Inbred Strains
Selection, Genetic*
Sex Factors
Social Environment
Species Specificity
Spleen / anatomy & histology
Stress, Psychological / blood*,  psychology
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Blood Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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